{"entity":{"id":"paper-eau-asco-penile-cancer-guideline-eur-urol-2023","kind":"paper","name":"EAU-ASCO collaborative guideline on penile cancer, 2023 update","aka":[],"tldr":"The joint European and American guideline for penile cancer, from HPV testing and organ-sparing surgery to sentinel node biopsy, lymph node surgery and chemotherapy for node-positive disease.","summary":"Collaborative guideline from the European Association of Urology and the American Society of Clinical Oncology covering diagnosis, HPV and p16 testing, penile-preserving treatment (topical therapy, laser, glansectomy, partial penectomy), management of the groin nodes with dynamic sentinel node biopsy or inguinal lymphadenectomy, neoadjuvant and adjuvant chemotherapy for node-positive disease, radiotherapy, follow-up and sexual and psychological support.\n\nIt grades the evidence, most of which is retrospective, and recommends referral to centralised centres and enrolment in trials such as InPACT.","asOf":"2026-09-18","links":[{"label":"Eur Urol 2023","url":"https://doi.org/10.1016/j.eururo.2023.02.027"},{"label":"PubMed","url":"https://pubmed.ncbi.nlm.nih.gov/36906413/"}],"tags":[],"related":[],"cancers":["localised-penile-cancer","node-positive-penile-cancer"],"sections":[],"technologies":[],"targets":[],"drugs":[],"companies":[],"institutions":[],"pathways":[],"terms":[],"trials":[],"people":[],"bottlenecks":[],"keyPapers":[],"journals":["european-urology"],"dependsOn":[],"notes":[],"journal":"European Urology","year":2023,"doi":"10.1016/j.eururo.2023.02.027","pmid":"36906413","authors":"Brouwer OR, Albersen M, Parnham A, et al.","paperType":"guideline","findings":[],"whatItMeans":"The standard-of-care entries on the penile cancer pages, from keeping as much of the penis as is safe to staging the groins with a sentinel node procedure, follow this guideline.","caveats":["Almost all recommendations rest on retrospective series; randomised evidence in penile cancer is limited to the InPACT trial.","Access to dynamic sentinel node biopsy is limited to specialised centres."],"changedPractice":true},"route":"/key-papers/paper-eau-asco-penile-cancer-guideline-eur-urol-2023/","neighbours":{"cancer":[{"id":"localised-penile-cancer","kind":"cancer","name":"Localised penile cancer (organ-confined, node-negative)","route":"/cancers/localised-penile-cancer/"},{"id":"node-positive-penile-cancer","kind":"cancer","name":"Node-positive and metastatic penile cancer","route":"/cancers/node-positive-penile-cancer/"}],"journal":[{"id":"european-urology","kind":"journal","name":"European Urology","route":"/journals/european-urology/"}]}}