{"entity":{"id":"paper-errani-wwtr1-camta1-ehe-gcc-2011","kind":"paper","name":"A novel WWTR1-CAMTA1 gene fusion is a consistent abnormality in epithelioid haemangioendothelioma","aka":[],"tldr":"This study identified the WWTR1-CAMTA1 gene fusion in nearly every epithelioid haemangioendothelioma from any body site, giving this rare vascular tumour a defining molecular marker.","summary":"Molecular study identifying a t(1;3) translocation fusing WWTR1 (encoding TAZ) to CAMTA1 in epithelioid haemangioendothelioma of soft tissue, bone, liver and lung, present in almost all cases and absent from other vascular tumours.","asOf":"2026-09-17","links":[{"label":"Genes Chromosomes Cancer 2011","url":"https://doi.org/10.1002/gcc.20886"},{"label":"PubMed","url":"https://pubmed.ncbi.nlm.nih.gov/21584898/"}],"tags":[],"related":[],"cancers":["epithelioid-haemangioendothelioma"],"sections":[],"technologies":[],"targets":[],"drugs":[],"companies":[],"institutions":[],"pathways":[],"terms":[],"trials":[],"people":[],"bottlenecks":[],"keyPapers":[],"journals":["genes-chromosomes-and-cancer"],"dependsOn":[],"notes":[],"journal":"Genes, chromosomes & cancer","year":2011,"doi":"10.1002/gcc.20886","pmid":"21584898","authors":"Errani C, Zhang L, Sung YS, et al.","paperType":"basic","findings":["WWTR1-CAMTA1 fusion in the vast majority of epithelioid haemangioendotheliomas across sites."],"whatItMeans":"CAMTA1 immunohistochemistry and fusion testing confirm the diagnosis, and the TAZ-CAMTA1 fusion protein's dependence on the Hippo pathway is guiding drug development.","caveats":["A minority of cases carry an alternative YAP1-TFE3 fusion."],"changedPractice":true},"route":"/key-papers/paper-errani-wwtr1-camta1-ehe-gcc-2011/","neighbours":{"cancer":[{"id":"epithelioid-haemangioendothelioma","kind":"cancer","name":"Epithelioid haemangioendothelioma","route":"/cancers/epithelioid-haemangioendothelioma/"}],"journal":[{"id":"genes-chromosomes-and-cancer","kind":"journal","name":"Genes, chromosomes & cancer","route":"/journals/genes-chromosomes-and-cancer/"}]}}