{"entity":{"id":"paper-esmo-bone-sarcoma-guideline-strauss-ann-oncol-2021","kind":"paper","name":"Bone sarcomas: ESMO-EURACAN-GENTURIS-ERN PaedCan clinical practice guideline","aka":[],"tldr":"The European guideline for bone sarcomas covers referral to specialist centres, biopsy, surgery, chemotherapy for osteosarcoma and Ewing sarcoma, and the surgery-based management of chondrosarcoma and chordoma including proton and carbon-ion radiotherapy.","summary":"Joint European guideline on the diagnosis, treatment and follow-up of bone sarcomas in adults and children, with sections on osteosarcoma, Ewing sarcoma, chondrosarcoma (including atypical cartilaginous tumour, dedifferentiated and mesenchymal subtypes), chordoma and giant cell tumour of bone.","asOf":"2026-09-17","links":[{"label":"Ann Oncol 2021","url":"https://doi.org/10.1016/j.annonc.2021.08.1995"},{"label":"PubMed","url":"https://pubmed.ncbi.nlm.nih.gov/34500044/"}],"tags":[],"related":[],"cancers":["chondrosarcoma"],"sections":[],"technologies":[],"targets":[],"drugs":[],"companies":[],"institutions":[],"pathways":[],"terms":[],"trials":[],"people":[],"bottlenecks":[],"keyPapers":[],"journals":["annals-of-oncology"],"dependsOn":[],"notes":[],"journal":"Annals of Oncology","year":2021,"doi":"10.1016/j.annonc.2021.08.1995","pmid":"34500044","authors":"Strauss SJ, Frezza AM, Abecassis N, et al.","paperType":"guideline","findings":[],"whatItMeans":"The chondrosarcoma page's recommendations for curettage of low-grade limb lesions, wide resection for higher grades and particle therapy for skull base tumours follow this guideline.","caveats":["Evidence for chemotherapy in dedifferentiated and mesenchymal chondrosarcoma remains weak."],"changedPractice":true},"route":"/key-papers/paper-esmo-bone-sarcoma-guideline-strauss-ann-oncol-2021/","neighbours":{"cancer":[{"id":"chondrosarcoma","kind":"cancer","name":"Chondrosarcoma","route":"/cancers/chondrosarcoma/"}],"journal":[{"id":"annals-of-oncology","kind":"journal","name":"Annals of Oncology","route":"/journals/annals-of-oncology/"}]}}