{"entity":{"id":"paper-esmo-mbc-living-guideline-update-ann-oncol-2025","kind":"paper","name":"Updated treatment recommendations for systemic treatment: from the ESMO Metastatic Breast Cancer Living Guideline","aka":[],"tldr":"A 2025 letter recording the latest changes to Europe's continuously updated guideline for metastatic breast cancer, the mechanism through which first-line antibody-drug conjugate results enter European practice.","summary":"Letter in Annals of Oncology (2025) by Trapani, Martins-Branco, Curigliano, Gennari and colleagues announcing updated systemic treatment recommendations from the ESMO Metastatic Breast Cancer Living Guideline. Europe PMC indexes no abstract, so OnCo carries no figures from it; the current recommendations are read from the living guideline on the ESMO website, which for triple-negative disease incorporates the first-line antibody-drug conjugate trials as they are published.","asOf":"2026-09-24","links":[{"label":"Ann Oncol 2025","url":"https://doi.org/10.1016/j.annonc.2025.07.017"},{"label":"PubMed","url":"https://pubmed.ncbi.nlm.nih.gov/40930896/"},{"label":"ESMO Metastatic Breast Cancer Living Guideline","url":"https://www.esmo.org/living-guidelines"}],"tags":["tnbc-evidence"],"related":["paper-esmo-metastatic-breast-cancer-guideline-ann-oncol-2021"],"cancers":["tnbc"],"sections":[],"technologies":[],"targets":[],"drugs":[],"companies":[],"institutions":["esmo"],"pathways":[],"terms":[],"trials":[],"people":["giuseppe-curigliano"],"bottlenecks":[],"keyPapers":[],"journals":["annals-of-oncology"],"dependsOn":[],"notes":[],"journal":"Annals of Oncology","year":2025,"doi":"10.1016/j.annonc.2025.07.017","pmid":"40930896","authors":"Trapani D, Martins-Branco D, Curigliano G, et al.","paperType":"guideline","findings":["No abstract is indexed on Europe PMC; the living guideline itself carries the recommendations."],"whatItMeans":"For a fast-moving disease the living guideline, not the 2021 paper, is where European recommendations for triple-negative breast cancer now change; readers should check the website rather than the journal.","caveats":["A letter announcing updates, not a full guideline text.","No abstract indexed."],"changedPractice":true},"route":"/key-papers/paper-esmo-mbc-living-guideline-update-ann-oncol-2025/","neighbours":{"paper":[{"id":"paper-esmo-metastatic-breast-cancer-guideline-ann-oncol-2021","kind":"paper","name":"ESMO Clinical Practice Guideline for the diagnosis, staging and treatment of patients with metastatic breast cancer","route":"/key-papers/paper-esmo-metastatic-breast-cancer-guideline-ann-oncol-2021/"}],"cancer":[{"id":"tnbc","kind":"cancer","name":"Triple-negative breast cancer (TNBC)","route":"/cancers/tnbc/"}],"institution":[{"id":"esmo","kind":"institution","name":"European Society for Medical Oncology (ESMO)","route":"/institutions/esmo/"}],"person":[{"id":"giuseppe-curigliano","kind":"person","name":"Giuseppe Curigliano","route":"/people/giuseppe-curigliano/"}],"journal":[{"id":"annals-of-oncology","kind":"journal","name":"Annals of Oncology","route":"/journals/annals-of-oncology/"}]}}