{"entity":{"id":"paper-esmo-rectal-cancer-guideline-ann-oncol-2017","kind":"paper","name":"Rectal cancer: ESMO Clinical Practice Guidelines for diagnosis, treatment and follow-up","aka":[],"tldr":"The European guideline for rectal cancer: how MRI decides the treatment, when radiotherapy is given before the operation, and how the mesorectum is removed.","summary":"ESMO Clinical Practice Guidelines for rectal cancer, published in Annals of Oncology in 2017 by Glynne-Jones, Wyrwicz, Tiret, Brown, Rödel, Cervantes and Arnold for the ESMO Guidelines Committee. Europe PMC indexes no abstract for this article, so OnCo carries no figures from it.\n\nIts organising idea is risk stratification by MRI: the distance from the tumour or an involved node to the mesorectal fascia, extramural venous invasion and nodal status decide whether a patient has surgery alone, short-course radiotherapy, or long-course chemoradiotherapy before total mesorectal excision.","asOf":"2026-09-24","links":[{"label":"Ann Oncol 2017","url":"https://doi.org/10.1093/annonc/mdx224"},{"label":"PubMed","url":"https://pubmed.ncbi.nlm.nih.gov/28881920/"}],"tags":["colorectal-evidence"],"related":["esmo-guidelines"],"cancers":["colorectal","rectal-cancer"],"sections":[],"technologies":["mri","radiotherapy","imrt-igrt"],"targets":[],"drugs":[],"companies":[],"institutions":["esmo"],"pathways":[],"terms":["total-mesorectal-excision","neoadjuvant-adjuvant","chemoradiation"],"trials":[],"people":["andres-cervantes"],"bottlenecks":[],"keyPapers":[],"journals":["annals-of-oncology"],"dependsOn":[],"notes":[],"journal":"Annals of Oncology","year":2017,"doi":"10.1093/annonc/mdx224","pmid":"28881920","authors":"Glynne-Jones R, Wyrwicz L, Tiret E, et al.","paperType":"guideline","findings":["No abstract is indexed on Europe PMC; recommendations are read from the guideline itself."],"whatItMeans":"The document behind the MRI-first rectal cancer pathway used across Europe and the UK; the total neoadjuvant therapy trials (RAPIDO, PRODIGE 23, OPRA) that came after it are the main reason an update was needed.","caveats":["Predates RAPIDO (2021), PRODIGE 23 (2021), OPRA (2022) and the dostarlimab organ-preservation series, all of which changed what is offered before surgery.","Guideline text, not a trial."],"changedPractice":true},"route":"/key-papers/paper-esmo-rectal-cancer-guideline-ann-oncol-2017/","neighbours":{"collection":[{"id":"esmo-guidelines","kind":"collection","name":"ESMO Clinical Practice Guidelines & MCBS","route":"/collections/esmo-guidelines/"}],"cancer":[{"id":"colorectal","kind":"cancer","name":"Colorectal cancer","route":"/cancers/colorectal/"},{"id":"rectal-cancer","kind":"cancer","name":"Rectal cancer","route":"/cancers/rectal-cancer/"}],"technology":[{"id":"imrt-igrt","kind":"technology","name":"IMRT / IGRT (modern external beam)","route":"/technologies/imrt-igrt/"},{"id":"mri","kind":"technology","name":"MRI","route":"/technologies/mri/"}],"term":[{"id":"chemoradiation","kind":"term","name":"Chemoradiation (chemoradiotherapy, CRT)","route":"/terms/chemoradiation/"},{"id":"neoadjuvant-adjuvant","kind":"term","name":"Neoadjuvant / adjuvant / perioperative","route":"/terms/neoadjuvant-adjuvant/"},{"id":"radiotherapy","kind":"term","name":"Radiotherapy","route":"/terms/radiotherapy/"},{"id":"total-mesorectal-excision","kind":"term","name":"Total mesorectal excision (TME)","route":"/terms/total-mesorectal-excision/"}],"institution":[{"id":"esmo","kind":"institution","name":"European Society for Medical Oncology (ESMO)","route":"/institutions/esmo/"}],"person":[{"id":"andres-cervantes","kind":"person","name":"Andrés Cervantes","route":"/people/andres-cervantes/"}],"journal":[{"id":"annals-of-oncology","kind":"journal","name":"Annals of Oncology","route":"/journals/annals-of-oncology/"}],"paper":[{"id":"paper-bahadoer-rapido-short-course-radiotherapy-lancet-oncol-2021","kind":"paper","name":"Short-course radiotherapy followed by chemotherapy before total mesorectal excision versus preoperative chemoradiotherapy in locally advanced rectal cancer (RAPIDO)","route":"/key-papers/paper-bahadoer-rapido-short-course-radiotherapy-lancet-oncol-2021/"}]}}