{"entity":{"id":"paper-esmo-sts-guideline-gronchi-ann-oncol-2021","kind":"paper","name":"Soft tissue and visceral sarcomas: ESMO-EURACAN-GENTURIS clinical practice guideline","aka":[],"tldr":"The European sarcoma guideline sets out referral to reference centres, biopsy and molecular diagnosis, surgery with radiotherapy for localised disease, the selective use of chemotherapy, and histology-driven treatment of advanced disease.","summary":"Joint European guideline covering the diagnosis, staging, multidisciplinary management and follow-up of soft tissue and visceral sarcomas in adults, including limb and trunk sarcomas, retroperitoneal sarcoma, gastrointestinal stromal tumour, desmoid tumours and subtype-specific systemic therapy recommendations.","asOf":"2026-09-17","links":[{"label":"Ann Oncol 2021","url":"https://doi.org/10.1016/j.annonc.2021.07.006"},{"label":"PubMed","url":"https://pubmed.ncbi.nlm.nih.gov/34303806/"}],"tags":[],"related":[],"cancers":["myxofibrosarcoma","undifferentiated-pleomorphic-sarcoma","extremity-soft-tissue-sarcoma","retroperitoneal-sarcoma","leiomyosarcoma","liposarcoma","pecoma","malignant-peripheral-nerve-sheath-tumour"],"sections":[],"technologies":[],"targets":[],"drugs":[],"companies":[],"institutions":[],"pathways":[],"terms":[],"trials":[],"people":[],"bottlenecks":[],"keyPapers":[],"journals":["annals-of-oncology"],"dependsOn":[],"notes":[],"journal":"Annals of Oncology","year":2021,"doi":"10.1016/j.annonc.2021.07.006","pmid":"34303806","authors":"Gronchi A, Miah AB, Dei Tos AP, et al.","paperType":"guideline","findings":[],"whatItMeans":"The general principles on the sarcoma subtype pages (reference centre surgery, radiotherapy for high-grade deep tumours, doxorubicin first line, histology-directed later lines) follow this guideline.","caveats":["Updated periodically; drug approvals since 2021 (for example nab-sirolimus, afamitresgene) are not covered."],"changedPractice":true},"route":"/key-papers/paper-esmo-sts-guideline-gronchi-ann-oncol-2021/","neighbours":{"cancer":[{"id":"leiomyosarcoma","kind":"cancer","name":"Leiomyosarcoma","route":"/cancers/leiomyosarcoma/"},{"id":"liposarcoma","kind":"cancer","name":"Liposarcoma","route":"/cancers/liposarcoma/"},{"id":"malignant-peripheral-nerve-sheath-tumour","kind":"cancer","name":"Malignant peripheral nerve sheath tumour (MPNST)","route":"/cancers/malignant-peripheral-nerve-sheath-tumour/"},{"id":"myxofibrosarcoma","kind":"cancer","name":"Myxofibrosarcoma","route":"/cancers/myxofibrosarcoma/"},{"id":"pecoma","kind":"cancer","name":"Perivascular epithelioid cell tumour (PEComa)","route":"/cancers/pecoma/"},{"id":"retroperitoneal-sarcoma","kind":"cancer","name":"Retroperitoneal sarcoma","route":"/cancers/retroperitoneal-sarcoma/"},{"id":"extremity-soft-tissue-sarcoma","kind":"cancer","name":"Soft tissue sarcoma of the extremity (localised and advanced)","route":"/cancers/extremity-soft-tissue-sarcoma/"},{"id":"undifferentiated-pleomorphic-sarcoma","kind":"cancer","name":"Undifferentiated pleomorphic sarcoma (UPS)","route":"/cancers/undifferentiated-pleomorphic-sarcoma/"}],"journal":[{"id":"annals-of-oncology","kind":"journal","name":"Annals of Oncology","route":"/journals/annals-of-oncology/"}]}}