{"entity":{"id":"paper-felsenstein-ipmn-cooccurring-cancer-relatedness-gut-2018","kind":"paper","name":"IPMNs with co-occurring invasive cancers: neighbours but not always relatives","aka":[],"tldr":"In 61 patients who had both a cyst and a pancreatic cancer removed, the two were genetically related in about half and unrelated in a fifth, so a cyst can be an innocent bystander to a cancer arising elsewhere.","summary":"All available patients with co-occurring IPMN and invasive intrapancreatic carcinoma over ten years at a single institution were analysed: DNA from the carcinoma, adjacent IPMN and distant IPMN underwent targeted next-generation sequencing of pancreatic cancer driver genes to infer relatedness. Of 61 patients with IPMN and ductal adenocarcinoma, 51% were likely related and 18% likely independent; all 13 IPMN and colloid carcinoma pairs were likely related. Striking genetic heterogeneity was found within IPMNs even for well-characterised driver genes.","asOf":"2026-09-24","links":[{"label":"Felsenstein et al., Gut 2018: IPMNs with co-occurring invasive cancers, related in 51% and independent in 18%","url":"https://doi.org/10.1136/gutjnl-2017-315062"},{"label":"PubMed","url":"https://pubmed.ncbi.nlm.nih.gov/29500184/"}],"tags":[],"related":[],"cancers":["pancreatic","ipmn-cystic-precursors"],"sections":[],"technologies":[],"targets":["kras","gnas","rnf43","tp53","smad4"],"drugs":[],"companies":[],"institutions":["johns-hopkins"],"pathways":["clonal-evolution"],"terms":[],"trials":[],"people":[],"bottlenecks":[],"keyPapers":[],"journals":["gut"],"dependsOn":[],"notes":[],"journal":"Gut","year":2018,"doi":"10.1136/gutjnl-2017-315062","pmid":"29500184","authors":"Felsenstein M, Noe M, Masica DL, et al.","paperType":"translational","findings":["Of 61 IPMN and ductal adenocarcinoma pairs, 51% likely related and 18% likely independent.","All 13 colloid carcinomas were related to their IPMN."],"whatItMeans":"Risk stratification of a cyst cannot assume the nearby cancer came from it, and the whole gland stays at risk after cyst resection.","caveats":["Single institution; relatedness inferred from a driver-gene panel.","Heterogeneity within IPMNs can misclassify relatedness."],"changedPractice":false,"participants":81},"route":"/key-papers/paper-felsenstein-ipmn-cooccurring-cancer-relatedness-gut-2018/","neighbours":{"cancer":[{"id":"ipmn-cystic-precursors","kind":"cancer","name":"Intraductal papillary mucinous neoplasm and other pancreatic cystic precursors","route":"/cancers/ipmn-cystic-precursors/"},{"id":"pancreatic","kind":"cancer","name":"Pancreatic ductal adenocarcinoma","route":"/cancers/pancreatic/"}],"target":[{"id":"gnas","kind":"target","name":"GNAS","route":"/targets/gnas/"},{"id":"kras","kind":"target","name":"KRAS","route":"/targets/kras/"},{"id":"rnf43","kind":"target","name":"RNF43","route":"/targets/rnf43/"},{"id":"smad4","kind":"target","name":"SMAD4","route":"/targets/smad4/"},{"id":"tp53","kind":"target","name":"TP53","route":"/targets/tp53/"}],"institution":[{"id":"johns-hopkins","kind":"institution","name":"Johns Hopkins Hospital / Sidney Kimmel Comprehensive Cancer Center","route":"/institutions/johns-hopkins/"}],"pathway":[{"id":"clonal-evolution","kind":"pathway","name":"Clonal evolution & minimal residual disease","route":"/pathways/clonal-evolution/"}],"journal":[{"id":"gut","kind":"journal","name":"Gut","route":"/journals/gut/"}]}}