{"entity":{"id":"paper-fiolet-bmj","kind":"paper","name":"Consumption of ultra-processed foods and cancer risk: results from NutriNet-Santé prospective cohort","aka":[],"tldr":"Paper cited by one technology page, indexed on Europe PMC as PubMed record 29444771 and published in BMJ; the citing page links this DOI, which is how the record was matched.","summary":"Objective: To assess the prospective associations between consumption of ultra-processed food and risk of cancer.\n\nDesign: Population based cohort study.\n\nSetting and participants: 104 980 participants aged at least 18 years (median age 42.8 years) from the French NutriNet-Santé cohort (2009-17). Dietary intakes were collected using repeated 24 hour dietary records, designed to register participants' usual consumption for 3300 different food items. These were categorised according to their degree of processing by the NOVA classification.\n\nMain outcome measures: Associations between ultra-processed food intake and risk of overall, breast, prostate, and colorectal cancer assessed by multivariable Cox proportional hazard models adjusted for known risk factors.\n\nResults: Ultra-processed food intake was associated with higher overall cancer risk (n=2228 cases; hazard ratio for a 10% increment in the proportion of ultra-processed food in the diet 1.12 (95% confidence interval 1.06 to 1.18); P for trend<0.001) and breast cancer risk (n=739 cases; hazard ratio 1.11 (1.02 to 1.22); P for trend=0.02). These results remained statistically significant after adjustment for several markers of the nutritional quality of the diet (lipid, sodium, and carbohydrate intakes and/or a Western pattern derived by principal component analysis).\n\nConclusions: In this large prospective study, a 10% increase in the proportion of ultra-processed foods in the diet was associated with a significant increase of greater than 10% in risks of overall and breast cancer. Further studies are needed to better understand the relative effect of the various dimensions of processing (nutritional composition, food additives, contact materials, and neoformed contaminants) in these associations.\n\nStudy registration: Clinicaltrials.gov NCT03335644.\n\nIndexed on Europe PMC as PubMed record 29444771 (DOI 10.1136/bmj.k322). Matched by DOI alone: one technology page cites this DOI among its external links (the pages are listed under Related), and this page was written so that the citation resolves inside OnCo. No figure has been checked by an editor.","asOf":"2026-09-22","links":[{"label":"BMJ 2018","url":"https://doi.org/10.1136/bmj.k322"},{"label":"PubMed","url":"https://pubmed.ncbi.nlm.nih.gov/29444771/"},{"label":"Europe PMC","url":"https://europepmc.org/article/MED/29444771"}],"tags":["europepmc-ingest"],"related":["ultra-processed-food-ssb"],"cancers":[],"sections":[],"technologies":[],"targets":[],"drugs":[],"companies":[],"institutions":[],"pathways":[],"terms":[],"trials":[],"people":[],"bottlenecks":[],"keyPapers":[],"journals":["bmj"],"dependsOn":[],"notes":[],"journal":"BMJ","year":2018,"doi":"10.1136/bmj.k322","pmid":"29444771","authors":"Fiolet T, Srour B, Sellem L, et al.","paperType":"rct","findings":[],"whatItMeans":"One technology page on OnCo cites this paper by its DOI; this record gives the citation a page of its own so a reader can follow it without leaving OnCo. Read the abstract above alongside the citing page listed under Related; the record was created automatically from the Europe PMC entry and its figures have not been checked by hand.","caveats":["Matched to the citing OnCo records by DOI alone; the summary reproduces the Europe PMC abstract and no figure has been verified against the full paper."]},"route":"/key-papers/paper-fiolet-bmj/","neighbours":{"technology":[{"id":"ultra-processed-food-ssb","kind":"technology","name":"Ultra-processed food and sugar-sweetened drinks","route":"/technologies/ultra-processed-food-ssb/"}],"journal":[{"id":"bmj","kind":"journal","name":"BMJ","route":"/journals/bmj/"}]}}