{"entity":{"id":"paper-flavahan-science","kind":"paper","name":"Epigenetic plasticity and the hallmarks of cancer","aka":[],"tldr":"Paper cited by one term page, indexed on Europe PMC as PubMed record 28729483 and published in Science; the citing page links this DOI, which is how the record was matched.","summary":"Chromatin and associated epigenetic mechanisms stabilize gene expression and cellular states while also facilitating appropriate responses to developmental or environmental cues. Genetic, environmental, or metabolic insults can induce overly restrictive or overly permissive epigenetic landscapes that contribute to pathogenesis of cancer and other diseases. Restrictive chromatin states may prevent appropriate induction of tumor suppressor programs or block differentiation. By contrast, permissive or \"plastic\" states may allow stochastic oncogene activation or nonphysiologic cell fate transitions. Whereas many stochastic events will be inconsequential \"passengers,\" some will confer a fitness advantage to a cell and be selected as \"drivers.\" We review the broad roles played by epigenetic aberrations in tumor initiation and evolution and their potential to give rise to all classic hallmarks of cancer.\n\nIndexed on Europe PMC as PubMed record 28729483 (DOI 10.1126/science.aal2380). Matched by DOI alone: one term page cites this DOI among its external links (the pages are listed under Related), and this page was written so that the citation resolves inside OnCo. No figure has been checked by an editor.","asOf":"2026-09-22","links":[{"label":"Science 2017","url":"https://doi.org/10.1126/science.aal2380"},{"label":"PubMed","url":"https://pubmed.ncbi.nlm.nih.gov/28729483/"},{"label":"Europe PMC","url":"https://europepmc.org/article/MED/28729483"}],"tags":["europepmc-ingest"],"related":["epigenetic-progenitor-theory"],"cancers":[],"sections":[],"technologies":[],"targets":[],"drugs":[],"companies":[],"institutions":[],"pathways":[],"terms":[],"trials":[],"people":[],"bottlenecks":[],"keyPapers":[],"journals":["science"],"dependsOn":[],"notes":[],"journal":"Science","year":2017,"doi":"10.1126/science.aal2380","pmid":"28729483","authors":"Flavahan WA, Gaskell E, Bernstein BE","paperType":"review","findings":[],"whatItMeans":"One term page on OnCo cites this paper by its DOI; this record gives the citation a page of its own so a reader can follow it without leaving OnCo. Read the abstract above alongside the citing page listed under Related; the record was created automatically from the Europe PMC entry and its figures have not been checked by hand.","caveats":["Matched to the citing OnCo records by DOI alone; the summary reproduces the Europe PMC abstract and no figure has been verified against the full paper."]},"route":"/key-papers/paper-flavahan-science/","neighbours":{"term":[{"id":"epigenetic-progenitor-theory","kind":"term","name":"Epigenetic progenitor theory: cancer without a first mutation","route":"/terms/epigenetic-progenitor-theory/"}],"journal":[{"id":"science","kind":"journal","name":"Science","route":"/journals/science/"}]}}