{"entity":{"id":"paper-freites-martinez-jama-dermatol","kind":"paper","name":"Endocrine Therapy-Induced Alopecia in Patients With Breast Cancer","aka":[],"tldr":"Paper cited by one technology page, indexed on Europe PMC as PubMed record 29641806 and published in JAMA dermatology; the citing page links this DOI, which is how the record was matched.","summary":"Importance: Endocrine therapy-induced alopecia (EIA) has been anecdotally reported but not systematically described.\n\nObjective: To characterize EIA in patients with breast cancer.\n\nDesign, setting, and participants: Retrospective cohort study of 112 patients with breast cancer, diagnosed with EIA from January 1, 2009, to December 31, 2016, the patients were examined at the dermatology service in a large tertiary care hospital and comprehensive cancer center.\n\nMain outcomes and measures: The clinical features, alopecia-related quality of life (QoL), and response to minoxidil of EIA in patients with breast cancer were assessed. Data from the Hairdex Questionnaire was used to assess the impact of the alopecia on patients QoL. Higher score indicates lower QoL (0-100 score). Efficacy of minoxidil was measured at 3 or 6 months by a single-blinded investigator through standardized clinical photographs of the scalp.\n\nResults: A total of 112 female patients with breast cancer were included (median [range] age, 60 [34-90] years). A total of 104 patients (93%) had standardized clinical photographs; of these, 59 patients (53%) had trichoscopy images available at baseline, and 46 patients (41%) were assessed for response to minoxidil. Alopecia was attributed to aromatase inhibitors in 75 patients (67%) and tamoxifen in 37 (33%). Severity was grade 1 in 96 of 104 patients (92%), and the pattern was similar to androgenetic alopecia. The predominant trichoscopic feature at baseline was the presence of vellus hairs and intermediate- and thick-diameter terminal hair shafts. A negative impact on QoL was reported, with a higher effect in the emotion domain according to the Hairdex score (mean [SD], 41.8 [21.3]; P <.001). After treatment with topical minoxidil, moderate or significant improvement in alopecia was observed in 37 of 46 patients (80%).\n\nConclusions and relevance: Endocrine therapies are associated with a pattern alopecia similar to androgenetic-type, consistent with the mechanism of action of causal agents. A significant negative impact on QoL was reported by patients, despite mostly mild alopecia severity.\n\nIndexed on Europe PMC as PubMed record 29641806 (DOI 10.1001/jamadermatol.2018.0454). Matched by DOI alone: one technology page cites this DOI among its external links (the pages are listed under Related), and this page was written so that the citation resolves inside OnCo. No figure has been checked by an editor.","asOf":"2026-09-22","links":[{"label":"JAMA Dermatol 2018","url":"https://doi.org/10.1001/jamadermatol.2018.0454"},{"label":"PubMed","url":"https://pubmed.ncbi.nlm.nih.gov/29641806/"},{"label":"Europe PMC","url":"https://europepmc.org/article/MED/29641806"}],"tags":["europepmc-ingest"],"related":["minoxidil-chemotherapy-alopecia"],"cancers":[],"sections":[],"technologies":[],"targets":[],"drugs":[],"companies":[],"institutions":[],"pathways":[],"terms":[],"trials":[],"people":[],"bottlenecks":[],"keyPapers":[],"journals":[],"dependsOn":[],"notes":[],"journal":"JAMA dermatology","year":2018,"doi":"10.1001/jamadermatol.2018.0454","pmid":"29641806","authors":"Freites-Martinez A, Shapiro J, Chan D, et al.","paperType":"observational","findings":[],"whatItMeans":"One technology page on OnCo cites this paper by its DOI; this record gives the citation a page of its own so a reader can follow it without leaving OnCo. Read the abstract above alongside the citing page listed under Related; the record was created automatically from the Europe PMC entry and its figures have not been checked by hand.","caveats":["Matched to the citing OnCo records by DOI alone; the summary reproduces the Europe PMC abstract and no figure has been verified against the full paper."]},"route":"/key-papers/paper-freites-martinez-jama-dermatol/","neighbours":{"technology":[{"id":"minoxidil-chemotherapy-alopecia","kind":"technology","name":"Minoxidil for persistent chemotherapy- and endocrine-therapy hair loss","route":"/technologies/minoxidil-chemotherapy-alopecia/"}]}}