{"entity":{"id":"paper-fushimi-androgen-deprivation-salivary-duct-ann-oncol-2018","kind":"paper","name":"Combined androgen blockade in androgen receptor-positive salivary gland carcinoma","aka":[],"tldr":"Hormone therapy of the kind used in prostate cancer shrank or controlled tumours in most patients with androgen receptor-positive salivary duct carcinoma, a treatment with far less toxicity than chemotherapy.","summary":"Prospective phase 2 study of 36 patients with androgen receptor-positive locally advanced or metastatic salivary gland carcinoma (predominantly salivary duct carcinoma) treated with leuprorelin and bicalutamide.\n\nObjective response was 41.7 percent with a clinical benefit rate of 75 percent, median progression-free survival 8.8 months and median overall survival 30.5 months, and toxicity was mild.","asOf":"2026-09-17","links":[{"label":"Ann Oncol 2018","url":"https://doi.org/10.1093/annonc/mdx771"},{"label":"PubMed","url":"https://pubmed.ncbi.nlm.nih.gov/29211833/"}],"tags":[],"related":[],"cancers":["salivary-duct-carcinoma"],"sections":[],"technologies":[],"targets":[],"drugs":[],"companies":[],"institutions":[],"pathways":[],"terms":[],"trials":[],"people":[],"bottlenecks":[],"keyPapers":[],"journals":["annals-of-oncology"],"dependsOn":[],"notes":[],"journal":"Annals of Oncology","year":2018,"doi":"10.1093/annonc/mdx771","pmid":"29211833","authors":"Fushimi C, Tada Y, Takahashi H, et al.","paperType":"observational","findings":["Objective response 41.7 percent; clinical benefit 75 percent.","Median progression-free survival 8.8 months; median overall survival 30.5 months."],"whatItMeans":"Androgen receptor testing and androgen deprivation therapy are now standard options for salivary duct carcinoma, often before chemotherapy in slowly progressing disease.","caveats":["Small single-arm trial; a subsequent randomised comparison with chemotherapy showed similar efficacy with less toxicity."],"changedPractice":true,"participants":36},"route":"/key-papers/paper-fushimi-androgen-deprivation-salivary-duct-ann-oncol-2018/","neighbours":{"cancer":[{"id":"salivary-duct-carcinoma","kind":"cancer","name":"Salivary duct carcinoma","route":"/cancers/salivary-duct-carcinoma/"}],"journal":[{"id":"annals-of-oncology","kind":"journal","name":"Annals of Oncology","route":"/journals/annals-of-oncology/"}]}}