{"entity":{"id":"paper-gerami-melanoma-gene-expression-profile-clin-cancer-res-2015","kind":"paper","name":"Development of a prognostic genetic signature to predict the metastatic risk associated with cutaneous melanoma","aka":[],"tldr":"The development of a gene-activity signature for skin melanoma that separated patients with a low and high chance of the cancer coming back.","summary":"A 28-gene signature (with control genes, the basis of the 31-gene test) classified primary melanomas; disease-free survival in the validation set was 97 per cent for class 1 and 31 per cent for class 2.","asOf":"2026-11-04","links":[{"label":"Gerami et al., Clin Cancer Res 2015","url":"https://doi.org/10.1158/1078-0432.CCR-13-3316"},{"label":"PubMed","url":"https://pubmed.ncbi.nlm.nih.gov/25564571/"}],"tags":[],"related":[],"cancers":["melanoma"],"sections":["diagnostics"],"technologies":["gene-expression-prognostic-assays"],"targets":[],"drugs":["decisiondx-melanoma"],"companies":[],"institutions":[],"pathways":[],"terms":["biomarker"],"trials":[],"people":[],"bottlenecks":[],"keyPapers":[],"journals":[],"dependsOn":[],"notes":[],"journal":"Clinical Cancer Research","year":2015,"doi":"10.1158/1078-0432.CCR-13-3316","pmid":"25564571","authors":"Gerami P, Cook RW, Wilkinson J, et al.","paperType":"translational","findings":["Validation disease-free survival 97% (class 1) and 31% (class 2)."],"whatItMeans":"Gene activity in the primary melanoma adds risk information to stage.","caveats":["Retrospective archival samples."]},"route":"/key-papers/paper-gerami-melanoma-gene-expression-profile-clin-cancer-res-2015/","neighbours":{"cancer":[{"id":"melanoma","kind":"cancer","name":"Melanoma","route":"/cancers/melanoma/"}],"section":[{"id":"diagnostics","kind":"section","name":"Diagnostics & Biomarkers","route":"/fronts/diagnostics/"}],"technology":[{"id":"gene-expression-prognostic-assays","kind":"technology","name":"Gene-expression prognostic assays","route":"/technologies/gene-expression-prognostic-assays/"}],"drug":[{"id":"decisiondx-melanoma","kind":"drug","name":"DecisionDx-Melanoma","route":"/drugs/decisiondx-melanoma/"}],"term":[{"id":"biomarker","kind":"term","name":"Biomarker","route":"/terms/biomarker/"}]}}