{"entity":{"id":"paper-gershenson-hormonal-maintenance-lgsoc-jco-2017","kind":"paper","name":"Hormonal maintenance therapy for women with low-grade serous cancer of the ovary or peritoneum","aka":[],"tldr":"In this retrospective study, women who took an aromatase inhibitor or other hormonal therapy after first-line surgery and chemotherapy for low-grade serous ovarian cancer had a median progression-free survival of over five years compared with about two years with observation.","summary":"Retrospective analysis of 203 women with stage II to IV low-grade serous carcinoma treated with primary surgery and platinum-based chemotherapy, comparing those who received hormonal maintenance therapy (mostly letrozole) with those observed.\n\nMedian progression-free survival was 64.9 months with hormonal maintenance against 26.4 months with observation, with the benefit maintained in women without residual disease and in a multivariable analysis.","asOf":"2026-09-17","links":[{"label":"J Clin Oncol 2017","url":"https://doi.org/10.1200/JCO.2016.71.0632"},{"label":"PubMed","url":"https://pubmed.ncbi.nlm.nih.gov/28221866/"}],"tags":[],"related":[],"cancers":["low-grade-serous-ovarian-cancer"],"sections":[],"technologies":[],"targets":[],"drugs":[],"companies":[],"institutions":[],"pathways":[],"terms":[],"trials":[],"people":[],"bottlenecks":[],"keyPapers":[],"journals":["jco"],"dependsOn":[],"notes":[],"journal":"Journal of Clinical Oncology","year":2017,"doi":"10.1200/JCO.2016.71.0632","pmid":"28221866","authors":"Gershenson DM, Bodurka DC, Coleman RL, et al.","paperType":"observational","findings":["Median progression-free survival 64.9 vs 26.4 months.","Benefit maintained in patients with no gross residual disease."],"whatItMeans":"Letrozole maintenance after first-line therapy is now common practice and guideline-supported for low-grade serous ovarian cancer, and the randomised NRG-GY019 trial is testing letrozole alone.","caveats":["Retrospective single-institution study with selection bias.","No overall survival difference."],"changedPractice":true,"participants":203},"route":"/key-papers/paper-gershenson-hormonal-maintenance-lgsoc-jco-2017/","neighbours":{"cancer":[{"id":"low-grade-serous-ovarian-cancer","kind":"cancer","name":"Low-grade serous ovarian cancer","route":"/cancers/low-grade-serous-ovarian-cancer/"}],"journal":[{"id":"jco","kind":"journal","name":"Journal of Clinical Oncology","route":"/journals/jco/"}]}}