{"entity":{"id":"paper-greaves-nature","kind":"paper","name":"Clonal evolution in cancer","aka":[],"tldr":"Paper cited by one pathway page and one term page, indexed on Europe PMC as PubMed record 22258609 and published in Nature; the citing pages link this DOI, which is how the record was matched.","summary":"Cancers evolve by a reiterative process of clonal expansion, genetic diversification and clonal selection within the adaptive landscapes of tissue ecosystems. The dynamics are complex, with highly variable patterns of genetic diversity and resulting clonal architecture. Therapeutic intervention may destroy cancer clones and erode their habitats, but it can also inadvertently provide a potent selective pressure for the expansion of resistant variants. The inherently Darwinian character of cancer is the primary reason for this therapeutic failure, but it may also hold the key to more effective control.\n\nIndexed on Europe PMC as PubMed record 22258609 (DOI 10.1038/nature10762). Matched by DOI alone: one pathway page and one term page cite this DOI among their external links (the pages are listed under Related), and this page was written so that the citation resolves inside OnCo. No figure has been checked by an editor.","asOf":"2026-09-22","links":[{"label":"Nature 2012","url":"https://doi.org/10.1038/nature10762"},{"label":"PubMed","url":"https://pubmed.ncbi.nlm.nih.gov/22258609/"},{"label":"Europe PMC","url":"https://europepmc.org/article/MED/22258609"}],"tags":["europepmc-ingest"],"related":["theories-of-cancer","clonal-evolution-theory"],"cancers":[],"sections":[],"technologies":[],"targets":[],"drugs":[],"companies":[],"institutions":[],"pathways":[],"terms":[],"trials":[],"people":[],"bottlenecks":[],"keyPapers":[],"journals":["nature"],"dependsOn":[],"notes":[],"journal":"Nature","year":2012,"doi":"10.1038/nature10762","pmid":"22258609","authors":"Greaves M, Maley CC","paperType":"review","findings":[],"whatItMeans":"One pathway page and one term page on OnCo cite this paper by its DOI; this record gives the citation a page of its own so a reader can follow it without leaving OnCo. Read the abstract above alongside the citing pages listed under Related; the record was created automatically from the Europe PMC entry and its figures have not been checked by hand.","caveats":["Matched to the citing OnCo records by DOI alone; the summary reproduces the Europe PMC abstract and no figure has been verified against the full paper."]},"route":"/key-papers/paper-greaves-nature/","neighbours":{"pathway":[{"id":"theories-of-cancer","kind":"pathway","name":"Theories of cancer: how the ideas connect","route":"/pathways/theories-of-cancer/"}],"term":[{"id":"clonal-evolution-theory","kind":"term","name":"Clonal evolution and the ecological view of cancer","route":"/terms/clonal-evolution-theory/"}],"journal":[{"id":"nature","kind":"journal","name":"Nature","route":"/journals/nature/"}]}}