{"entity":{"id":"paper-groinss-v-sentinel-node-vulvar-cancer-jco-2008","kind":"paper","name":"GROINSS-V: sentinel node dissection is safe in early-stage vulvar cancer","aka":[],"tldr":"Removing only the first draining lymph node in the groin, and leaving the rest when it was clear, was safe for women with small vulvar cancers: very few groins relapsed and the swelling and wound problems of full groin surgery were largely avoided.","summary":"Prospective multicentre observational study of 403 women with unifocal vulvar squamous cell carcinoma under 4 cm and clinically negative groins who had sentinel node detection with radiotracer and blue dye; inguinofemoral lymphadenectomy was omitted when the sentinel node was negative.\n\nGroin recurrence occurred in 2.3 percent of women with a negative sentinel node, three-year survival was 97 percent, and wound breakdown, infection and lymphoedema were far less common than after full lymphadenectomy. The procedure became the standard for early vulvar cancer.","asOf":"2026-09-18","links":[{"label":"J Clin Oncol 2008","url":"https://doi.org/10.1200/JCO.2007.14.0566"},{"label":"PubMed","url":"https://pubmed.ncbi.nlm.nih.gov/18281661/"}],"tags":[],"related":[],"cancers":["hpv-associated-vulvar-cancer","hpv-independent-vulvar-cancer"],"sections":[],"technologies":[],"targets":[],"drugs":[],"companies":[],"institutions":[],"pathways":[],"terms":[],"trials":[],"people":[],"bottlenecks":[],"keyPapers":[],"journals":["jco"],"dependsOn":[],"notes":[],"journal":"Journal of Clinical Oncology","year":2008,"doi":"10.1200/JCO.2007.14.0566","pmid":"18281661","authors":"Van der Zee AG, Oonk MH, De Hullu JA, et al.","paperType":"observational","findings":["Groin recurrence in 2.3 percent of sentinel-node-negative women; three-year disease-specific survival 97 percent.","Short-term wound complications and lymphoedema much less frequent than after inguinofemoral lymphadenectomy."],"whatItMeans":"Women with small, unifocal vulvar cancers and clinically negative groins can be staged with a sentinel node procedure and spared full groin dissection when the node is clear.","caveats":["Applies only to unifocal tumours under 4 cm with clinically negative groins, in centres experienced in the technique.","Not randomised against lymphadenectomy."],"changedPractice":true,"participants":403},"route":"/key-papers/paper-groinss-v-sentinel-node-vulvar-cancer-jco-2008/","neighbours":{"cancer":[{"id":"hpv-associated-vulvar-cancer","kind":"cancer","name":"HPV-associated vulvar squamous cell carcinoma","route":"/cancers/hpv-associated-vulvar-cancer/"},{"id":"hpv-independent-vulvar-cancer","kind":"cancer","name":"HPV-independent vulvar squamous cell carcinoma (p53-mutant)","route":"/cancers/hpv-independent-vulvar-cancer/"}],"journal":[{"id":"jco","kind":"journal","name":"Journal of Clinical Oncology","route":"/journals/jco/"}]}}