{"entity":{"id":"paper-hanahan-cancer-cell","kind":"paper","name":"Accessories to the crime: functions of cells recruited to the tumor microenvironment","aka":[],"tldr":"Paper cited by one term page, indexed on Europe PMC as PubMed record 22439926 and published in Cancer Cell; the citing page links this DOI, which is how the record was matched.","summary":"Mutationally corrupted cancer (stem) cells are the driving force of tumor development and progression. Yet, these transformed cells cannot do it alone. Assemblages of ostensibly normal tissue and bone marrow-derived (stromal) cells are recruited to constitute tumorigenic microenvironments. Most of the hallmarks of cancer are enabled and sustained to varying degrees through contributions from repertoires of stromal cell types and distinctive subcell types. Their contributory functions to hallmark capabilities are increasingly well understood, as are the reciprocal communications with neoplastic cancer cells that mediate their recruitment, activation, programming, and persistence. This enhanced understanding presents interesting new targets for anticancer therapy.\n\nIndexed on Europe PMC as PubMed record 22439926 (DOI 10.1016/j.ccr.2012.02.022). Matched by DOI alone: one term page cites this DOI among its external links (the pages are listed under Related), and this page was written so that the citation resolves inside OnCo. No figure has been checked by an editor.","asOf":"2026-09-22","links":[{"label":"Cancer Cell 2012","url":"https://doi.org/10.1016/j.ccr.2012.02.022"},{"label":"PubMed","url":"https://pubmed.ncbi.nlm.nih.gov/22439926/"},{"label":"Europe PMC","url":"https://europepmc.org/article/MED/22439926"}],"tags":["europepmc-ingest"],"related":["microenvironment-inflammation-theory"],"cancers":[],"sections":[],"technologies":[],"targets":[],"drugs":[],"companies":[],"institutions":[],"pathways":[],"terms":[],"trials":[],"people":[],"bottlenecks":[],"keyPapers":[],"journals":["cancer-cell"],"dependsOn":[],"notes":[],"journal":"Cancer Cell","year":2012,"doi":"10.1016/j.ccr.2012.02.022","pmid":"22439926","authors":"Hanahan D, Coussens LM","paperType":"review","findings":[],"whatItMeans":"One term page on OnCo cites this paper by its DOI; this record gives the citation a page of its own so a reader can follow it without leaving OnCo. Read the abstract above alongside the citing page listed under Related; the record was created automatically from the Europe PMC entry and its figures have not been checked by hand.","caveats":["Matched to the citing OnCo records by DOI alone; the summary reproduces the Europe PMC abstract and no figure has been verified against the full paper."]},"route":"/key-papers/paper-hanahan-cancer-cell/","neighbours":{"term":[{"id":"microenvironment-inflammation-theory","kind":"term","name":"Microenvironment and inflammation: tumours as wounds that do not heal","route":"/terms/microenvironment-inflammation-theory/"}],"journal":[{"id":"cancer-cell","kind":"journal","name":"Cancer Cell","route":"/journals/cancer-cell/"}]}}