{"entity":{"id":"paper-hayashi-squamous-basal-like-pancreatic-nat-cancer-2020","kind":"paper","name":"A unifying paradigm for transcriptional heterogeneity and squamous features in pancreatic ductal adenocarcinoma","aka":[],"tldr":"Sampling several regions of metastatic pancreatic cancers showed that squamous-looking areas are the tissue form of the basal-like gene signature, usually a subclone inside an otherwise classical tumour, and that such cancers carry chromatin-gene mutations and uneven MYC gain.","summary":"Evolutionary analysis and expression profiling were integrated in multiregion-sampled metastatic pancreatic cancers. Squamous features were the histological correlate of the RNA-seq-defined basal-like subtype. In patients with coexisting basal-squamous and classical-glandular morphology, phylogenetics showed squamous morphology as a subclonal population within an otherwise classical tumour. Cancers with squamous features were more likely to have clonal mutations in chromatin modifiers, intercellular heterogeneity for MYC amplification and entosis.","asOf":"2026-09-24","links":[{"label":"Hayashi et al., Nat Cancer 2020: squamous features are the histological correlate of basal-like expression","url":"https://doi.org/10.1038/s43018-019-0010-1"},{"label":"PubMed","url":"https://pubmed.ncbi.nlm.nih.gov/35118421/"}],"tags":[],"related":[],"cancers":["pancreatic","metastatic-pdac"],"sections":[],"technologies":[],"targets":["myc-gene","kdm6a"],"drugs":[],"companies":[],"institutions":["mskcc"],"pathways":["myc","clonal-evolution","swi-snf-chromatin"],"terms":[],"trials":[],"people":[],"bottlenecks":[],"keyPapers":[],"journals":["nature-cancer"],"dependsOn":[],"notes":[],"journal":"Nature Cancer","year":2020,"doi":"10.1038/s43018-019-0010-1","pmid":"35118421","authors":"Hayashi A, Fan J, Chen R, et al.","paperType":"translational","findings":["Squamous histology is the tissue correlate of basal-like expression and usually subclonal.","Squamous-feature cancers carry clonal chromatin-modifier mutations and heterogeneous MYC amplification."],"whatItMeans":"It joins the pathology (adenosquamous), the transcriptome (basal-like) and the genome (KDM6A, MYC) into one account of the chemotherapy-resistant subtype, and shows a single biopsy can miss it.","caveats":["Rapid-autopsy metastatic cohort.","Entosis and MYC heterogeneity are descriptive findings."],"changedPractice":false},"route":"/key-papers/paper-hayashi-squamous-basal-like-pancreatic-nat-cancer-2020/","neighbours":{"cancer":[{"id":"metastatic-pdac","kind":"cancer","name":"Metastatic pancreatic ductal adenocarcinoma","route":"/cancers/metastatic-pdac/"},{"id":"pancreatic","kind":"cancer","name":"Pancreatic ductal adenocarcinoma","route":"/cancers/pancreatic/"}],"target":[{"id":"kdm6a","kind":"target","name":"KDM6A","route":"/targets/kdm6a/"},{"id":"myc-gene","kind":"target","name":"MYC","route":"/targets/myc-gene/"}],"institution":[{"id":"mskcc","kind":"institution","name":"Memorial Sloan Kettering Cancer Center","route":"/institutions/mskcc/"}],"pathway":[{"id":"clonal-evolution","kind":"pathway","name":"Clonal evolution & minimal residual disease","route":"/pathways/clonal-evolution/"},{"id":"myc","kind":"pathway","name":"MYC","route":"/pathways/myc/"},{"id":"swi-snf-chromatin","kind":"pathway","name":"SWI/SNF chromatin remodelling","route":"/pathways/swi-snf-chromatin/"}],"journal":[{"id":"nature-cancer","kind":"journal","name":"Nature Cancer","route":"/journals/nature-cancer/"}]}}