{"entity":{"id":"paper-heeke-alk-ctrna-ctdna-jto-clin-res-rep-2025","kind":"paper","name":"Longitudinal Tracking of ALK-Rearranged NSCLC From Plasma Using Circulating Tumor RNA and Circulating Tumor DNA","aka":[],"tldr":"A lung cancer study that tracked ALK fusions in blood using both RNA and DNA, finding some only in the RNA.","summary":"ALK rearrangements were detected in 15 of 28 patients at baseline, eight in both circulating tumour DNA and RNA; in two patients they were found before local consolidative therapy only in the RNA and cleared afterwards. The authors conclude that including circulating tumour RNA increased detection.","asOf":"2026-11-04","links":[{"label":"Heeke et al., JTO Clin Res Rep 2025","url":"https://doi.org/10.1016/j.jtocrr.2025.100795"},{"label":"PubMed","url":"https://pubmed.ncbi.nlm.nih.gov/40160974/"}],"tags":[],"related":[],"cancers":["alk-positive-nsclc"],"sections":["diagnostics"],"technologies":["liquid-rna-biopsy","liquid-biopsy"],"targets":[],"drugs":[],"companies":[],"institutions":[],"pathways":[],"terms":["ctdna"],"trials":[],"people":[],"bottlenecks":[],"keyPapers":[],"journals":[],"dependsOn":[],"notes":[],"journal":"JTO Clinical and Research Reports","year":2025,"doi":"10.1016/j.jtocrr.2025.100795","pmid":"40160974","authors":"Heeke S, Gandhi S, Tran HT, et al.","paperType":"translational","findings":["ALK found in 15 of 28 at baseline; 2 patients only in RNA."],"whatItMeans":"Same-draw RNA and DNA together catch fusions one alone misses.","caveats":["Small cohort; advanced disease."],"participants":33},"route":"/key-papers/paper-heeke-alk-ctrna-ctdna-jto-clin-res-rep-2025/","neighbours":{"cancer":[{"id":"alk-positive-nsclc","kind":"cancer","name":"ALK-positive non-small-cell lung cancer","route":"/cancers/alk-positive-nsclc/"}],"section":[{"id":"diagnostics","kind":"section","name":"Diagnostics & Biomarkers","route":"/fronts/diagnostics/"}],"technology":[{"id":"liquid-biopsy","kind":"technology","name":"Liquid biopsy (ctDNA)","route":"/technologies/liquid-biopsy/"},{"id":"liquid-rna-biopsy","kind":"technology","name":"Liquid RNA biopsy (cell-free, vesicle and platelet RNA)","route":"/technologies/liquid-rna-biopsy/"}],"term":[{"id":"ctdna","kind":"term","name":"Circulating tumour DNA (ctDNA)","route":"/terms/ctdna/"}],"idea":[{"id":"idea-stack-ctdna-and-tumour-rna-residual-disease","kind":"idea","name":"Read tumour RNA and tumour DNA from the same blood draw to find and type residual cancer","route":"/ideas/idea-stack-ctdna-and-tumour-rna-residual-disease/"}]}}