{"entity":{"id":"paper-herbst-nature","kind":"paper","name":"The biology and management of non-small cell lung cancer","aka":[],"tldr":"Paper cited by one pathway page, indexed on Europe PMC as PubMed record 29364287 and published in Nature; the citing page links this DOI, which is how the record was matched.","summary":"Important advancements in the treatment of non-small cell lung cancer (NSCLC) have been achieved over the past two decades, increasing our understanding of the disease biology and mechanisms of tumour progression, and advancing early detection and multimodal care. The use of small molecule tyrosine kinase inhibitors and immunotherapy has led to unprecedented survival benefits in selected patients. However, the overall cure and survival rates for NSCLC remain low, particularly in metastatic disease. Therefore, continued research into new drugs and combination therapies is required to expand the clinical benefit to a broader patient population and to improve outcomes in NSCLC.\n\nIndexed on Europe PMC as PubMed record 29364287 (DOI 10.1038/nature25183). Matched by DOI alone: one pathway page cites this DOI among its external links (the pages are listed under Related), and this page was written so that the citation resolves inside OnCo. No figure has been checked by an editor.","asOf":"2026-09-22","links":[{"label":"Nature 2018","url":"https://doi.org/10.1038/nature25183"},{"label":"PubMed","url":"https://pubmed.ncbi.nlm.nih.gov/29364287/"},{"label":"Europe PMC","url":"https://europepmc.org/article/MED/29364287"}],"tags":["europepmc-ingest"],"related":["nsclc-signalling"],"cancers":[],"sections":[],"technologies":[],"targets":[],"drugs":[],"companies":[],"institutions":[],"pathways":[],"terms":[],"trials":[],"people":[],"bottlenecks":[],"keyPapers":[],"journals":["nature"],"dependsOn":[],"notes":[],"journal":"Nature","year":2018,"doi":"10.1038/nature25183","pmid":"29364287","authors":"Herbst RS, Morgensztern D, Boshoff C","paperType":"review","findings":[],"whatItMeans":"One pathway page on OnCo cites this paper by its DOI; this record gives the citation a page of its own so a reader can follow it without leaving OnCo. Read the abstract above alongside the citing page listed under Related; the record was created automatically from the Europe PMC entry and its figures have not been checked by hand.","caveats":["Matched to the citing OnCo records by DOI alone; the summary reproduces the Europe PMC abstract and no figure has been verified against the full paper."]},"route":"/key-papers/paper-herbst-nature/","neighbours":{"pathway":[{"id":"nsclc-signalling","kind":"pathway","name":"Non-small cell lung cancer (KEGG map)","route":"/pathways/nsclc-signalling/"}],"journal":[{"id":"nature","kind":"journal","name":"Nature","route":"/journals/nature/"}]}}