{"entity":{"id":"paper-hinestrosa-ev-protein-commun-med-2022","kind":"paper","name":"Early-stage multi-cancer detection using an extracellular vesicle protein-based blood test","aka":[],"tldr":"A pilot study found that proteins on tiny vesicles shed into blood could pick out early pancreatic, ovarian and bladder cancers from people without cancer.","summary":"Hinestrosa and colleagues purified extracellular vesicles from plasma with an alternating current electrokinetics platform and built a machine-learning classifier on vesicle protein measurements. In a case-control pilot of 139 stage I and II pancreatic, ovarian or bladder cancers against 184 controls, the area under the curve was 0.95, with sensitivity 71.2% (63.2 to 78.1) at 99.5% specificity; stage I sensitivity was 70.5%, reaching 95.5% in pancreatic, 74.4% in ovarian and 43.8% in bladder cancer.","asOf":"2026-10-29","links":[{"label":"Communications Medicine 2022","url":"https://doi.org/10.1038/s43856-022-00088-6"},{"label":"PubMed","url":"https://pubmed.ncbi.nlm.nih.gov/35603292/"}],"tags":[],"related":[],"cancers":["pancreatic","ovarian","urothelial"],"sections":["early-detection"],"technologies":["mced","proteomics"],"targets":[],"drugs":[],"companies":[],"institutions":[],"pathways":[],"terms":[],"trials":[],"people":[],"bottlenecks":[],"keyPapers":[],"journals":[],"dependsOn":[],"notes":[],"journal":"Communications Medicine","year":2022,"doi":"10.1038/s43856-022-00088-6","pmid":"35603292","authors":"Hinestrosa JP, Kurzrock R, Lewis JM, et al.","paperType":"translational","findings":["Sensitivity 71.2% at 99.5% specificity for stage I and II cancers of three types.","Stage I sensitivity 70.5%."],"whatItMeans":"Proof of principle in three cancers from a small case-control set; it is not a screening result.","caveats":["Pilot case-control study of 323 people.","Three cancer types only."],"changedPractice":false,"participants":323},"route":"/key-papers/paper-hinestrosa-ev-protein-commun-med-2022/","neighbours":{"cancer":[{"id":"urothelial","kind":"cancer","name":"Bladder & urothelial cancer","route":"/cancers/urothelial/"},{"id":"ovarian","kind":"cancer","name":"Ovarian cancer","route":"/cancers/ovarian/"},{"id":"pancreatic","kind":"cancer","name":"Pancreatic ductal adenocarcinoma","route":"/cancers/pancreatic/"}],"section":[{"id":"early-detection","kind":"section","name":"Early Detection & Screening","route":"/fronts/early-detection/"}],"technology":[{"id":"mced","kind":"technology","name":"Multi-cancer early detection (MCED)","route":"/technologies/mced/"},{"id":"proteomics","kind":"technology","name":"Proteomics & phosphoproteomics","route":"/technologies/proteomics/"}]}}