{"entity":{"id":"paper-hunger-mullighan-all-children-nejm-2015","kind":"paper","name":"Acute lymphoblastic leukaemia in children (review)","aka":[],"tldr":"This review summarises how childhood acute lymphoblastic leukaemia became curable in nine of ten children through risk-adapted chemotherapy, and how genomic subtypes such as Ph-like and infant leukaemia are shaping the next generation of targeted treatment.","summary":"Review of the epidemiology, genomic classification (including Ph-like ALL, IKZF1 alterations, KMT2A rearrangements, hypodiploidy), risk stratification by measurable residual disease, treatment phases, outcomes approaching 90 percent survival, late effects, relapse and emerging immunotherapies for childhood ALL.","asOf":"2026-09-17","links":[{"label":"N Engl J Med 2015","url":"https://doi.org/10.1056/NEJMra1400972"},{"label":"PubMed","url":"https://pubmed.ncbi.nlm.nih.gov/26465987/"}],"tags":[],"related":[],"cancers":["all-paediatric-high-risk","all-ph-like","all-infant"],"sections":[],"technologies":[],"targets":[],"drugs":[],"companies":[],"institutions":[],"pathways":[],"terms":[],"trials":[],"people":[],"bottlenecks":[],"keyPapers":[],"journals":["nejm"],"dependsOn":[],"notes":[],"journal":"New England Journal of Medicine","year":2015,"doi":"10.1056/NEJMra1400972","pmid":"26465987","authors":"Hunger SP, Mullighan CG.","paperType":"review","findings":[],"whatItMeans":"The structure of the paediatric ALL subtype pages, from risk groups to new targeted and immune therapies, follows the framework in this review.","caveats":["Predates blinatumomab and CAR-T results in frontline therapy."],"changedPractice":false},"route":"/key-papers/paper-hunger-mullighan-all-children-nejm-2015/","neighbours":{"cancer":[{"id":"all-paediatric-high-risk","kind":"cancer","name":"High-risk acute lymphoblastic leukaemia in children (high-risk B-ALL and T-ALL)","route":"/cancers/all-paediatric-high-risk/"},{"id":"all-infant","kind":"cancer","name":"Infant acute lymphoblastic leukaemia (KMT2A-rearranged, under one year)","route":"/cancers/all-infant/"},{"id":"all-ph-like","kind":"cancer","name":"Philadelphia chromosome-like acute lymphoblastic leukaemia (Ph-like or BCR::ABL1-like ALL)","route":"/cancers/all-ph-like/"}],"journal":[{"id":"nejm","kind":"journal","name":"New England Journal of Medicine","route":"/journals/nejm/"}]}}