{"entity":{"id":"paper-ielsg37-pmbcl-martelli-jco-2024","kind":"paper","name":"IELSG37: omission of radiotherapy in primary mediastinal B-cell lymphoma after a negative PET scan","aka":[],"tldr":"Patients with primary mediastinal B-cell lymphoma whose PET scan was negative after immunochemotherapy did just as well without consolidation radiotherapy as with it, so radiotherapy can safely be omitted for them.","summary":"Phase 3 non-inferiority trial of 545 patients with primary mediastinal B-cell lymphoma treated with rituximab-containing immunochemotherapy; the 268 with a complete metabolic response on PET were randomised to observation or consolidation mediastinal radiotherapy.\n\nThirty-month progression-free survival was 96.2 percent with observation and 98.5 percent with radiotherapy, meeting non-inferiority, with overall survival of 99 percent in both arms.","asOf":"2026-09-17","links":[{"label":"J Clin Oncol 2024","url":"https://doi.org/10.1200/JCO-24-01373"},{"label":"PubMed","url":"https://pubmed.ncbi.nlm.nih.gov/39159403/"}],"tags":[],"related":[],"cancers":["primary-mediastinal-b-cell-lymphoma"],"sections":[],"technologies":[],"targets":[],"drugs":[],"companies":[],"institutions":[],"pathways":[],"terms":[],"trials":["ielsg37"],"people":[],"bottlenecks":[],"keyPapers":[],"journals":["jco"],"dependsOn":[],"notes":[],"journal":"Journal of Clinical Oncology","year":2024,"doi":"10.1200/JCO-24-01373","pmid":"39159403","authors":"Martelli M, Ceriani L, Ciccone G, et al.","paperType":"rct","findings":["30-month progression-free survival 96.2 percent (observation) vs 98.5 percent (radiotherapy); non-inferior.","Overall survival 99 percent in both arms."],"whatItMeans":"End-of-treatment PET now decides radiotherapy in primary mediastinal B-cell lymphoma: a negative scan means no radiotherapy, whichever chemotherapy regimen was used.","caveats":["Patients with residual PET uptake were not randomised and mostly received radiotherapy.","Long-term second cancer data are pending."],"changedPractice":true,"participants":545},"route":"/key-papers/paper-ielsg37-pmbcl-martelli-jco-2024/","neighbours":{"cancer":[{"id":"primary-mediastinal-b-cell-lymphoma","kind":"cancer","name":"Primary mediastinal (thymic) large B-cell lymphoma","route":"/cancers/primary-mediastinal-b-cell-lymphoma/"}],"trial":[{"id":"ielsg37","kind":"trial","name":"IELSG37","route":"/trials/ielsg37/"}],"journal":[{"id":"jco","kind":"journal","name":"Journal of Clinical Oncology","route":"/journals/jco/"}]}}