{"entity":{"id":"paper-imatinib-dfsp-eortc-swog-rutkowski-jco-2010","kind":"paper","name":"Imatinib in advanced dermatofibrosarcoma protuberans: pooled analysis of two phase 2 trials (EORTC 62027 and SWOG S0345)","aka":[],"tldr":"Pooling two trials, imatinib shrank tumours in about half of patients with locally advanced or metastatic dermatofibrosarcoma protuberans, confirming that blocking the PDGF receptor works in this fusion-driven sarcoma.","summary":"Pooled analysis of 24 patients with locally advanced or metastatic dermatofibrosarcoma protuberans treated with imatinib in the EORTC 62027 (800 mg) and SWOG S0345 (400 mg) phase 2 trials, both closed early for slow accrual.\n\nObjective response was 46 percent, with median time to progression of 1.7 years, and responses were similar at both doses; tumours with fibrosarcomatous transformation also responded.","asOf":"2026-09-17","links":[{"label":"J Clin Oncol 2010","url":"https://doi.org/10.1200/JCO.2009.25.7899"},{"label":"PubMed","url":"https://pubmed.ncbi.nlm.nih.gov/20194851/"}],"tags":[],"related":[],"cancers":["dermatofibrosarcoma-protuberans"],"sections":[],"technologies":[],"targets":[],"drugs":["imatinib"],"companies":[],"institutions":[],"pathways":[],"terms":[],"trials":[],"people":[],"bottlenecks":[],"keyPapers":[],"journals":["jco"],"dependsOn":[],"notes":[],"journal":"Journal of Clinical Oncology","year":2010,"doi":"10.1200/JCO.2009.25.7899","pmid":"20194851","authors":"Rutkowski P, Van Glabbeke M, Rankin CJ, et al.","paperType":"observational","findings":["Objective response 46 percent.","Median time to progression 1.7 years; no dose-response difference between 400 and 800 mg."],"whatItMeans":"Imatinib is the standard systemic treatment for unresectable, recurrent or metastatic dermatofibrosarcoma protuberans and is used neoadjuvantly to shrink large tumours before surgery.","caveats":["Small pooled cohort from two prematurely closed trials."],"changedPractice":true,"participants":24},"route":"/key-papers/paper-imatinib-dfsp-eortc-swog-rutkowski-jco-2010/","neighbours":{"cancer":[{"id":"dermatofibrosarcoma-protuberans","kind":"cancer","name":"Dermatofibrosarcoma protuberans","route":"/cancers/dermatofibrosarcoma-protuberans/"}],"drug":[{"id":"imatinib","kind":"drug","name":"Imatinib","route":"/drugs/imatinib/"}],"journal":[{"id":"jco","kind":"journal","name":"Journal of Clinical Oncology","route":"/journals/jco/"}]}}