{"entity":{"id":"paper-imwg-criteria-rajkumar-lancet-oncol-2014","kind":"paper","name":"IMWG updated criteria for the diagnosis of multiple myeloma (2014)","aka":[],"tldr":"The 2014 International Myeloma Working Group criteria allow myeloma to be diagnosed and treated before organ damage occurs when biomarkers such as 60 percent marrow plasma cells or a very high light-chain ratio predict imminent progression.","summary":"Updated diagnostic criteria adding three myeloma-defining biomarkers (clonal marrow plasma cells 60 percent or more, involved to uninvolved free light chain ratio 100 or more, more than one focal lesion on MRI) to the classic CRAB features, and revising the definitions of smouldering myeloma and related plasma cell disorders.","asOf":"2026-09-17","links":[{"label":"Lancet Oncol 2014","url":"https://doi.org/10.1016/S1470-2045(14)70442-5"},{"label":"PubMed","url":"https://pubmed.ncbi.nlm.nih.gov/25439696/"}],"tags":[],"related":[],"cancers":["smouldering-myeloma","plasma-cell-leukaemia"],"sections":[],"technologies":[],"targets":[],"drugs":[],"companies":[],"institutions":[],"pathways":[],"terms":[],"trials":[],"people":[],"bottlenecks":[],"keyPapers":[],"journals":["lancet-oncology"],"dependsOn":[],"notes":[],"journal":"The Lancet Oncology","year":2014,"doi":"10.1016/S1470-2045(14)70442-5","pmid":"25439696","authors":"Rajkumar SV, Dimopoulos MA, Palumbo A, et al.","paperType":"guideline","findings":[],"whatItMeans":"Whether a patient is labelled smouldering or active myeloma, and therefore whether treatment starts, depends on these criteria.","caveats":["Biomarker thresholds were based on retrospective cohorts and continue to be refined."],"changedPractice":true},"route":"/key-papers/paper-imwg-criteria-rajkumar-lancet-oncol-2014/","neighbours":{"cancer":[{"id":"plasma-cell-leukaemia","kind":"cancer","name":"Plasma cell leukaemia","route":"/cancers/plasma-cell-leukaemia/"},{"id":"smouldering-myeloma","kind":"cancer","name":"Smouldering multiple myeloma","route":"/cancers/smouldering-myeloma/"}],"journal":[{"id":"lancet-oncology","kind":"journal","name":"The Lancet Oncology","route":"/journals/lancet-oncology/"}]}}