{"entity":{"id":"paper-ishiguro-dichloroacetate-ivermectin-cureus-2022","kind":"paper","name":"Synergistic anti-tumor effect of dichloroacetate and ivermectin","aka":[],"tldr":"Three patients treated at a private clinic with dichloroacetate, omeprazole, tamoxifen and ivermectin were reported to have relief of symptoms; there was no control, no measured tumour response and no follow-up study.","summary":"The authors, who had earlier proposed that dichloroacetate, omeprazole and tamoxifen block cancer progression by reducing lactic acid production, present three patients in whom adding ivermectin was said to have 'dramatically relieved' the symptoms of cancer and sarcoma progression (Ishiguro case series 2022). The report describes symptom relief rather than tumour measurements (Ishiguro case series 2022).","asOf":"2026-09-24","links":[{"label":"Ishiguro case series 2022","url":"https://doi.org/10.7759/cureus.21884"},{"label":"PubMed","url":"https://pubmed.ncbi.nlm.nih.gov/35265417/"}],"tags":[],"related":[],"cancers":[],"sections":[],"technologies":[],"targets":[],"drugs":["ivermectin"],"companies":[],"institutions":[],"pathways":[],"terms":[],"trials":[],"people":[],"bottlenecks":[],"keyPapers":[],"journals":[],"dependsOn":[],"notes":[],"provenance":{"editedBy":"OnCo agent (Claude Fable 5.1)","editedOn":"2026-09-24","note":"Written from cached ClinicalTrials.gov v2, Europe PMC, DailyMed, Drugs@FDA and WHO eEML responses; no figure appears without its source link."},"journal":"Cureus","year":2022,"doi":"10.7759/cureus.21884","pmid":"35265417","authors":"Ishiguro T, Ishiguro RH, Ishiguro M, Toki A, Terunuma H.","paperType":"observational","findings":["Three patients; symptom relief reported; no objective response measured."],"whatItMeans":"An anecdote from the clinic that prescribed the regimen; it cannot show benefit and has not led to a trial.","caveats":["No control group, no tumour measurements, authors treated the patients they report on."],"changedPractice":false,"participants":3},"route":"/key-papers/paper-ishiguro-dichloroacetate-ivermectin-cureus-2022/","neighbours":{"drug":[{"id":"ivermectin","kind":"drug","name":"Ivermectin","route":"/drugs/ivermectin/"}]}}