{"entity":{"id":"paper-jcog0912-katai-lancet-gastroenterol-hepatol-2020","kind":"paper","name":"JCOG0912: laparoscopy-assisted versus open distal gastrectomy for clinical stage IA or IB gastric cancer","aka":[],"tldr":"Japan's randomised trial confirmed that laparoscopy-assisted distal gastrectomy is not inferior to open surgery for relapse-free survival in stage I gastric cancer, cementing the minimally invasive approach.","summary":"Phase 3 non-inferiority trial of 921 patients with clinical stage IA or IB gastric cancer randomised to laparoscopy-assisted or open distal gastrectomy with D1+ or D2 lymphadenectomy at Japanese centres.\n\nFive-year relapse-free survival was 95.1 percent with laparoscopic and 94.0 percent with open surgery, meeting non-inferiority, with similar overall survival and no differences in long-term complications.","asOf":"2026-09-17","links":[{"label":"Lancet Gastroenterol Hepatol 2020","url":"https://doi.org/10.1016/S2468-1253(19)30332-2"},{"label":"PubMed","url":"https://pubmed.ncbi.nlm.nih.gov/31757656/"}],"tags":[],"related":[],"cancers":["early-gastric-cancer"],"sections":[],"technologies":[],"targets":[],"drugs":[],"companies":[],"institutions":[],"pathways":[],"terms":[],"trials":["klass-01"],"people":[],"bottlenecks":[],"keyPapers":[],"journals":[],"dependsOn":[],"notes":[],"journal":"The Lancet Gastroenterology and Hepatology","year":2020,"doi":"10.1016/S2468-1253(19)30332-2","pmid":"31757656","authors":"Katai H, Mizusawa J, Katayama H, et al.","paperType":"rct","findings":["Five-year relapse-free survival 95.1 percent (laparoscopic) vs 94.0 percent (open); non-inferior."],"whatItMeans":"Together with KLASS-01, this trial makes laparoscopic distal gastrectomy the standard for early gastric cancer needing surgery.","caveats":["Applies to distal tumours; total gastrectomy and advanced disease were studied separately."],"changedPractice":true,"participants":921},"route":"/key-papers/paper-jcog0912-katai-lancet-gastroenterol-hepatol-2020/","neighbours":{"cancer":[{"id":"early-gastric-cancer","kind":"cancer","name":"Early gastric cancer","route":"/cancers/early-gastric-cancer/"}],"trial":[{"id":"klass-01","kind":"trial","name":"KLASS-01","route":"/trials/klass-01/"}]}}