{"entity":{"id":"paper-jshbps-biliary-tract-cancer-guidelines-2019-jhbps-2021","kind":"paper","name":"Clinical practice guidelines for the management of biliary tract cancers 2019: The 3rd English edition","aka":[],"tldr":"Japan's surgical society guideline for bile duct, gallbladder and ampullary cancer, the only major guideline with a section on preventive treatment.","summary":"Third English edition of the Japanese Society of Hepato-Biliary-Pancreatic Surgery guidelines, first issued in 2007 and revised in 2014. Thirty-one clinical questions cover six topics: prophylactic treatment, diagnosis, biliary drainage, surgical treatment, chemotherapy and radiation therapy, graded with GRADE as strong (14 recommendations) or weak (14), with three questions left without a recommendation.","asOf":"2026-09-24","links":[{"label":"J Hepatobiliary Pancreat Sci 2021","url":"https://doi.org/10.1002/jhbp.870"},{"label":"PubMed","url":"https://pubmed.ncbi.nlm.nih.gov/33259690/"}],"tags":["gallbladder-evidence"],"related":[],"cancers":["gallbladder","cholangiocarcinoma","ampullary"],"sections":[],"technologies":[],"targets":[],"drugs":[],"companies":[],"institutions":[],"pathways":[],"terms":["radical-cholecystectomy","prophylactic-cholecystectomy"],"trials":[],"people":[],"bottlenecks":[],"keyPapers":[],"journals":[],"dependsOn":[],"notes":[],"journal":"Journal of Hepato-Biliary-Pancreatic Sciences","year":2021,"doi":"10.1002/jhbp.870","pmid":"33259690","authors":"Nagino M, Hirano S, Yoshitomi H, et al.","paperType":"guideline","findings":["31 clinical questions across six topics including prophylactic treatment.","14 strong and 14 weak recommendations; three questions with no recommendation."],"whatItMeans":"Japanese surgeons operate on gallbladder cancer far more often than UK surgeons and their guideline addresses prevention (pancreaticobiliary maljunction, polyps) as a clinical topic, which Western guidelines do not.","caveats":["Surgical-society guideline; systemic therapy sections predate the immunotherapy trials.","Evidence for many surgical questions is retrospective."],"changedPractice":true},"route":"/key-papers/paper-jshbps-biliary-tract-cancer-guidelines-2019-jhbps-2021/","neighbours":{"cancer":[{"id":"ampullary","kind":"cancer","name":"Ampullary cancer (ampulla of Vater)","route":"/cancers/ampullary/"},{"id":"cholangiocarcinoma","kind":"cancer","name":"Biliary tract cancer (cholangiocarcinoma)","route":"/cancers/cholangiocarcinoma/"},{"id":"gallbladder","kind":"cancer","name":"Gallbladder cancer","route":"/cancers/gallbladder/"}],"term":[{"id":"prophylactic-cholecystectomy","kind":"term","name":"Prophylactic (preventive) cholecystectomy","route":"/terms/prophylactic-cholecystectomy/"},{"id":"radical-cholecystectomy","kind":"term","name":"Radical (extended) cholecystectomy","route":"/terms/radical-cholecystectomy/"}]}}