{"entity":{"id":"paper-kalra-bre09-146-rucaparib-npj-2021","kind":"paper","name":"BRE09-146: cisplatin with or without rucaparib after preoperative breast chemotherapy","aka":[],"tldr":"Adding low-dose rucaparib to cisplatin did not significantly improve the main outcome after surgery. Limited drug exposure makes this an incomplete test of other PARP strategies.","summary":"Randomized postoperative TNBC or BRCA-mutated breast trial with residual invasive tumour greater than 2 cm or persistent nodal involvement after neoadjuvant therapy. Patients received cisplatin alone or with low-dose rucaparib; accrual occurred in 2010 to 2013.","asOf":"2026-10-10","links":[{"label":"Primary publication","url":"https://doi.org/10.1038/s41523-021-00240-w"},{"label":"PubMed record","url":"https://pubmed.ncbi.nlm.nih.gov/33753748/"}],"tags":[],"related":[],"cancers":["breast-cancer","tnbc"],"sections":[],"technologies":[],"targets":["parp"],"drugs":["rucaparib","cisplatin"],"companies":[],"institutions":[],"pathways":[],"terms":[],"trials":["nct01074970"],"people":[],"bottlenecks":[],"keyPapers":[],"journals":[],"dependsOn":[],"notes":[],"journal":"npj Breast Cancer","year":2021,"doi":"10.1038/s41523-021-00240-w","pmid":"33753748","authors":"Kalra M, Tong Y, Jones DR, et al.","paperType":"rct","findings":["Two-year DFS: 54.2% with cisplatin versus 64.1% with cisplatin/rucaparib; p=0.29.","Rucaparib exposure was limited; the authors concluded the tested regimen did not improve two-year DFS."],"whatItMeans":"Negative result for the tested low-exposure combination; not proof that every rucaparib or PARP strategy fails.","caveats":["Negative result for the tested low-exposure combination; not proof that every rucaparib or PARP strategy fails.","Predates modern neoadjuvant chemoimmunotherapy and did not establish somatic-BRCA selection."],"participants":128},"route":"/key-papers/paper-kalra-bre09-146-rucaparib-npj-2021/","neighbours":{"cancer":[{"id":"breast-cancer","kind":"cancer","name":"Breast cancer (all types)","route":"/cancers/breast-cancer/"},{"id":"tnbc","kind":"cancer","name":"Triple-negative breast cancer (TNBC)","route":"/cancers/tnbc/"}],"target":[{"id":"parp","kind":"target","name":"PARP","route":"/targets/parp/"}],"drug":[{"id":"cisplatin","kind":"drug","name":"Cisplatin","route":"/drugs/cisplatin/"},{"id":"rucaparib","kind":"drug","name":"Rucaparib","route":"/drugs/rucaparib/"}],"trial":[{"id":"nct01074970","kind":"trial","name":"BRE09-146: postoperative cisplatin with or without rucaparib","route":"/trials/nct01074970/"}]}}