{"entity":{"id":"paper-karimzadeh-oncrna-lung-cancer-nat-commun-2024","kind":"paper","name":"Deep generative AI models analyzing circulating orphan non-coding RNAs enable detection of early-stage lung cancer","aka":[],"tldr":"Exai Bio's study of small RNAs found in tumours but not normal tissue, read from blood serum to detect lung cancer.","summary":"In serum from 1,050 people with non-small cell lung cancer and matched controls, the Orion model achieved an overall sensitivity of 94 per cent (95% CI 87 to 98) at 87 per cent (95% CI 81 to 93) specificity across all stages on held-out validation data.","asOf":"2026-11-04","links":[{"label":"Karimzadeh et al., Nat Commun 2024","url":"https://doi.org/10.1038/s41467-024-53851-9"},{"label":"PubMed","url":"https://pubmed.ncbi.nlm.nih.gov/39572521/"}],"tags":[],"related":[],"cancers":["nsclc"],"sections":["early-detection"],"technologies":["liquid-rna-biopsy"],"targets":[],"drugs":[],"companies":["exai-bio"],"institutions":[],"pathways":[],"terms":["biomarker"],"trials":[],"people":[],"bottlenecks":[],"keyPapers":[],"journals":[],"dependsOn":[],"notes":[],"journal":"Nature Communications","year":2024,"doi":"10.1038/s41467-024-53851-9","pmid":"39572521","authors":"Karimzadeh M, Momen-Roknabadi A, Cavazos TB, et al.","paperType":"translational","findings":["Sensitivity 94% at 87% specificity."],"whatItMeans":"Tumour-specific small RNAs are readable in serum; the specificity is too low for population screening as reported.","caveats":["Case-control design; company authors."],"participants":1050},"route":"/key-papers/paper-karimzadeh-oncrna-lung-cancer-nat-commun-2024/","neighbours":{"cancer":[{"id":"nsclc","kind":"cancer","name":"Non-small-cell lung cancer","route":"/cancers/nsclc/"}],"section":[{"id":"early-detection","kind":"section","name":"Early Detection & Screening","route":"/fronts/early-detection/"}],"technology":[{"id":"liquid-rna-biopsy","kind":"technology","name":"Liquid RNA biopsy (cell-free, vesicle and platelet RNA)","route":"/technologies/liquid-rna-biopsy/"}],"company":[{"id":"exai-bio","kind":"company","name":"Exai Bio","route":"/companies/exai-bio/"}],"term":[{"id":"biomarker","kind":"term","name":"Biomarker","route":"/terms/biomarker/"}]}}