{"entity":{"id":"paper-kastenhuber-cell","kind":"paper","name":"Putting p53 in Context","aka":[],"tldr":"Paper cited by one pathway page, indexed on Europe PMC as PubMed record 28886379 and published in Cell; the citing page links this DOI, which is how the record was matched.","summary":"TP53 is the most frequently mutated gene in human cancer. Functionally, p53 is activated by a host of stress stimuli and, in turn, governs an exquisitely complex anti-proliferative transcriptional program that touches upon a bewildering array of biological responses. Despite the many unveiled facets of the p53 network, a clear appreciation of how and in what contexts p53 exerts its diverse effects remains unclear. How can we interpret p53's disparate activities and the consequences of its dysfunction to understand how cell type, mutation profile, and epigenetic cell state dictate outcomes, and how might we restore its tumor-suppressive activities in cancer?\n\nIndexed on Europe PMC as PubMed record 28886379 (DOI 10.1016/j.cell.2017.08.028). Matched by DOI alone: one pathway page cites this DOI among its external links (the pages are listed under Related), and this page was written so that the citation resolves inside OnCo. No figure has been checked by an editor.","asOf":"2026-09-22","links":[{"label":"Cell 2017","url":"https://doi.org/10.1016/j.cell.2017.08.028"},{"label":"PubMed","url":"https://pubmed.ncbi.nlm.nih.gov/28886379/"},{"label":"Europe PMC","url":"https://europepmc.org/article/MED/28886379"}],"tags":["europepmc-ingest"],"related":["p53-mdm2-axis"],"cancers":[],"sections":[],"technologies":[],"targets":[],"drugs":[],"companies":[],"institutions":[],"pathways":[],"terms":[],"trials":[],"people":[],"bottlenecks":[],"keyPapers":[],"journals":["cell"],"dependsOn":[],"notes":[],"journal":"Cell","year":2017,"doi":"10.1016/j.cell.2017.08.028","pmid":"28886379","authors":"Kastenhuber ER, Lowe SW","paperType":"review","findings":[],"whatItMeans":"One pathway page on OnCo cites this paper by its DOI; this record gives the citation a page of its own so a reader can follow it without leaving OnCo. Read the abstract above alongside the citing page listed under Related; the record was created automatically from the Europe PMC entry and its figures have not been checked by hand.","caveats":["Matched to the citing OnCo records by DOI alone; the summary reproduces the Europe PMC abstract and no figure has been verified against the full paper."]},"route":"/key-papers/paper-kastenhuber-cell/","neighbours":{"pathway":[{"id":"p53-mdm2-axis","kind":"pathway","name":"The p53 network (guardian of the genome)","route":"/pathways/p53-mdm2-axis/"}],"journal":[{"id":"cell","kind":"journal","name":"Cell","route":"/journals/cell/"}]}}