{"entity":{"id":"paper-kerr-92-gene-cancer-classifier-clin-cancer-res-2012","kind":"paper","name":"Multisite validation study to determine performance characteristics of a 92-gene molecular cancer classifier","aka":[],"tldr":"A blinded multisite study of 790 tumours showing how often a 92-gene test named a cancer's tissue of origin correctly.","summary":"Overall sensitivity was 87 per cent for tumour type and 82 per cent for subtype.","asOf":"2026-11-04","links":[{"label":"Kerr et al., Clin Cancer Res 2012","url":"https://doi.org/10.1158/1078-0432.CCR-12-0920"},{"label":"PubMed","url":"https://pubmed.ncbi.nlm.nih.gov/22648269/"}],"tags":[],"related":[],"cancers":["cancer-of-unknown-primary"],"sections":["diagnostics"],"technologies":["gene-expression-prognostic-assays"],"targets":[],"drugs":["cancertype-id"],"companies":[],"institutions":[],"pathways":[],"terms":["biomarker"],"trials":[],"people":[],"bottlenecks":[],"keyPapers":[],"journals":[],"dependsOn":[],"notes":[],"journal":"Clinical Cancer Research","year":2012,"doi":"10.1158/1078-0432.CCR-12-0920","pmid":"22648269","authors":"Kerr SE, Schnabel CA, Sullivan PS, et al.","paperType":"translational","findings":["Sensitivity 87% for tumour type and 82% for subtype."],"whatItMeans":"Gene activity often points to where a cancer of unknown primary started.","caveats":["Tumours of known origin were used as the reference."],"participants":790},"route":"/key-papers/paper-kerr-92-gene-cancer-classifier-clin-cancer-res-2012/","neighbours":{"cancer":[{"id":"cancer-of-unknown-primary","kind":"cancer","name":"Cancer of unknown primary (CUP)","route":"/cancers/cancer-of-unknown-primary/"}],"section":[{"id":"diagnostics","kind":"section","name":"Diagnostics & Biomarkers","route":"/fronts/diagnostics/"}],"technology":[{"id":"gene-expression-prognostic-assays","kind":"technology","name":"Gene-expression prognostic assays","route":"/technologies/gene-expression-prognostic-assays/"}],"drug":[{"id":"cancertype-id","kind":"drug","name":"CancerTYPE ID","route":"/drugs/cancertype-id/"}],"term":[{"id":"biomarker","kind":"term","name":"Biomarker","route":"/terms/biomarker/"}]}}