{"entity":{"id":"paper-klass-01-kim-jama-oncol-2019","kind":"paper","name":"KLASS-01: laparoscopic versus open distal gastrectomy for stage I gastric cancer, long-term survival","aka":[],"tldr":"Keyhole removal of the lower stomach for early gastric cancer gave the same five-year survival as open surgery in this large Korean trial, confirming laparoscopic gastrectomy as a standard for stage I disease.","summary":"Phase 3 non-inferiority trial of 1,416 patients with clinical stage I gastric cancer randomised to laparoscopic or open distal gastrectomy in 13 Korean centres.\n\nFive-year overall survival was 94.2 percent with laparoscopic and 93.3 percent with open surgery, cancer-specific survival 97.1 versus 97.2 percent, with fewer wound complications after laparoscopic surgery as reported earlier.","asOf":"2026-09-17","links":[{"label":"JAMA Oncol 2019","url":"https://doi.org/10.1001/jamaoncol.2018.6727"},{"label":"PubMed","url":"https://pubmed.ncbi.nlm.nih.gov/30730546/"}],"tags":[],"related":[],"cancers":["early-gastric-cancer"],"sections":[],"technologies":[],"targets":[],"drugs":[],"companies":[],"institutions":[],"pathways":[],"terms":[],"trials":["klass-01"],"people":[],"bottlenecks":[],"keyPapers":[],"journals":["jama-oncology"],"dependsOn":[],"notes":[],"journal":"JAMA Oncology","year":2019,"doi":"10.1001/jamaoncol.2018.6727","pmid":"30730546","authors":"Kim HH, Han SU, Kim MC, et al.","paperType":"rct","findings":["Five-year overall survival 94.2 percent vs 93.3 percent (non-inferior).","Five-year cancer-specific survival 97.1 percent vs 97.2 percent."],"whatItMeans":"Laparoscopic distal gastrectomy is the standard operation for stage I gastric cancer outside endoscopic criteria in East Asia and increasingly elsewhere.","caveats":["High-volume Korean surgeons; results may not generalise to low-volume settings."],"changedPractice":true,"participants":1416},"route":"/key-papers/paper-klass-01-kim-jama-oncol-2019/","neighbours":{"cancer":[{"id":"early-gastric-cancer","kind":"cancer","name":"Early gastric cancer","route":"/cancers/early-gastric-cancer/"}],"trial":[{"id":"klass-01","kind":"trial","name":"KLASS-01","route":"/trials/klass-01/"}],"journal":[{"id":"jama-oncology","kind":"journal","name":"JAMA Oncology","route":"/journals/jama-oncology/"}]}}