{"entity":{"id":"paper-krijgsman-blueprint-subtyping-breast-cancer-res-treat-2012","kind":"paper","name":"A diagnostic gene profile for molecular subtyping of breast cancer associated with treatment response","aka":[],"tldr":"The development of the 80-gene BluePrint profile, which sorts breast cancers into three biological types that differed in response to chemotherapy before surgery.","summary":"The 80-gene profile classified tumours as luminal-type, HER2-type or basal-type. In the neoadjuvant cohort, 56 per cent of patients in the basal-type group and 50 per cent in the HER2-type group had a pathological complete response.","asOf":"2026-11-04","links":[{"label":"Krijgsman et al., Breast Cancer Res Treat 2012","url":"https://doi.org/10.1007/s10549-011-1683-z"},{"label":"PubMed","url":"https://pubmed.ncbi.nlm.nih.gov/21814749/"}],"tags":[],"related":[],"cancers":["breast-cancer"],"sections":["diagnostics"],"technologies":["gene-expression-prognostic-assays"],"targets":[],"drugs":["blueprint"],"companies":[],"institutions":[],"pathways":[],"terms":["biomarker"],"trials":[],"people":[],"bottlenecks":[],"keyPapers":[],"journals":[],"dependsOn":[],"notes":[],"journal":"Breast Cancer Research and Treatment","year":2012,"doi":"10.1007/s10549-011-1683-z","pmid":"21814749","authors":"Krijgsman O, Roepman P, Zwart W, et al.","paperType":"translational","findings":["Pathological complete response 56% in basal-type and 50% in HER2-type tumours."],"whatItMeans":"Gene activity can refine the subtype that standard receptor staining gives.","caveats":["Development study by the maker's scientists."]},"route":"/key-papers/paper-krijgsman-blueprint-subtyping-breast-cancer-res-treat-2012/","neighbours":{"cancer":[{"id":"breast-cancer","kind":"cancer","name":"Breast cancer (all types)","route":"/cancers/breast-cancer/"}],"section":[{"id":"diagnostics","kind":"section","name":"Diagnostics & Biomarkers","route":"/fronts/diagnostics/"}],"technology":[{"id":"gene-expression-prognostic-assays","kind":"technology","name":"Gene-expression prognostic assays","route":"/technologies/gene-expression-prognostic-assays/"}],"drug":[{"id":"blueprint","kind":"drug","name":"BluePrint","route":"/drugs/blueprint/"}],"term":[{"id":"biomarker","kind":"term","name":"Biomarker","route":"/terms/biomarker/"}]}}