{"entity":{"id":"paper-kroep-mpnst-first-line-chemotherapy-ann-oncol-2011","kind":"paper","name":"First-line chemotherapy for malignant peripheral nerve sheath tumour versus other soft tissue sarcomas (EORTC pooled analysis)","aka":[],"tldr":"Pooling twelve EORTC trials showed that malignant peripheral nerve sheath tumours respond to doxorubicin-ifosfamide about as well as other sarcomas, though survival is shorter, and that NF1-associated tumours may respond less.","summary":"Retrospective analysis of 175 patients with malignant peripheral nerve sheath tumour among 2,675 soft tissue sarcoma patients treated with first-line anthracycline-based chemotherapy in EORTC trials.\n\nResponse rate was 21 percent in MPNST compared with 22 percent in other sarcomas, with the highest response to doxorubicin-ifosfamide; median overall survival was 48 weeks against 51 weeks, and NF1-associated tumours tended to respond less.","asOf":"2026-09-17","links":[{"label":"Ann Oncol 2011","url":"https://doi.org/10.1093/annonc/mdq338"},{"label":"PubMed","url":"https://pubmed.ncbi.nlm.nih.gov/20656792/"}],"tags":[],"related":[],"cancers":["malignant-peripheral-nerve-sheath-tumour"],"sections":[],"technologies":[],"targets":[],"drugs":[],"companies":[],"institutions":[],"pathways":[],"terms":[],"trials":[],"people":[],"bottlenecks":[],"keyPapers":[],"journals":["annals-of-oncology"],"dependsOn":[],"notes":[],"journal":"Annals of Oncology","year":2011,"doi":"10.1093/annonc/mdq338","pmid":"20656792","authors":"Kroep JR, Ouali M, Gelderblom H, et al.","paperType":"observational","findings":["Objective response 21 percent in MPNST vs 22 percent in other sarcomas.","Median overall survival 48 weeks; lower response in NF1-associated MPNST."],"whatItMeans":"Doxorubicin-ifosfamide is the standard first-line chemotherapy for advanced MPNST, and the analysis supports treating it like other high-grade sarcomas while recognising its poorer prognosis.","caveats":["Retrospective pooled analysis across trials spanning decades."],"changedPractice":true,"participants":175},"route":"/key-papers/paper-kroep-mpnst-first-line-chemotherapy-ann-oncol-2011/","neighbours":{"cancer":[{"id":"malignant-peripheral-nerve-sheath-tumour","kind":"cancer","name":"Malignant peripheral nerve sheath tumour (MPNST)","route":"/cancers/malignant-peripheral-nerve-sheath-tumour/"}],"journal":[{"id":"annals-of-oncology","kind":"journal","name":"Annals of Oncology","route":"/journals/annals-of-oncology/"}]}}