{"entity":{"id":"paper-la-rosa-acinar-cell-carcinoma-62-cases-ajsp-2012","kind":"paper","name":"La Rosa 2012: clinicopathologic study of 62 acinar cell carcinomas of the pancreas","aka":[],"tldr":"The largest single pathology series of acinar cell carcinoma, from a European network, confirmed which stains identify the tumour, described its variants and showed that stage at diagnosis is what determines survival.","summary":"Multicentre European series of 62 acinar cell carcinomas of the pancreas with detailed morphology, immunohistochemistry and follow-up. The study compared the sensitivity of trypsin, chymotrypsin, lipase and BCL10 as markers of acinar differentiation, characterised mixed acinar-neuroendocrine and acinar-ductal tumours, and examined the acinar cell cystadenocarcinoma variant.\n\nSurvival was better than in ductal adenocarcinoma but depended strongly on stage: patients with localised, resected tumours could survive for years while metastatic disease behaved aggressively. Trypsin and BCL10 were the most useful diagnostic markers.","asOf":"2026-09-21","links":[{"label":"Am J Surg Pathol 2012","url":"https://doi.org/10.1097/PAS.0b013e318263209d"},{"label":"PubMed","url":"https://pubmed.ncbi.nlm.nih.gov/23026929/"}],"tags":[],"related":[],"cancers":["pancreatic-acinar-cell-carcinoma","pancreatic"],"sections":[],"technologies":[],"targets":[],"drugs":[],"companies":[],"institutions":[],"pathways":[],"terms":[],"trials":[],"people":[],"bottlenecks":[],"keyPapers":[],"journals":[],"dependsOn":[],"notes":[],"journal":"American Journal of Surgical Pathology","year":2012,"doi":"10.1097/PAS.0b013e318263209d","pmid":"23026929","authors":"La Rosa S, Adsay V, Albarello L, et al.","paperType":"observational","findings":["Trypsin and BCL10 immunostains were the most sensitive markers of acinar differentiation.","Stage (tumour size, nodal and distant spread) was the dominant prognostic factor; resected localised tumours had a favourable course."],"whatItMeans":"The paper underpins the WHO diagnostic criteria for acinar cell carcinoma and its variants and supports aggressive surgery for localised disease.","caveats":["Retrospective pathology series with heterogeneous treatment.","Molecular characterisation was not part of this study; the genomic profile came later."],"participants":62},"route":"/key-papers/paper-la-rosa-acinar-cell-carcinoma-62-cases-ajsp-2012/","neighbours":{"cancer":[{"id":"pancreatic-acinar-cell-carcinoma","kind":"cancer","name":"Pancreatic acinar cell carcinoma","route":"/cancers/pancreatic-acinar-cell-carcinoma/"},{"id":"pancreatic","kind":"cancer","name":"Pancreatic ductal adenocarcinoma","route":"/cancers/pancreatic/"}]}}