{"entity":{"id":"paper-ladanyi-aspl-tfe3-oncogene-2001","kind":"paper","name":"The der(17)t(X;17) of alveolar soft part sarcoma fuses TFE3 to ASPL","aka":[],"tldr":"This study identified the ASPL-TFE3 gene fusion created by the characteristic chromosome translocation in alveolar soft part sarcoma, giving the disease a defining molecular marker and a diagnostic test.","summary":"Molecular cloning of the unbalanced der(17)t(X;17)(p11;q25) translocation in alveolar soft part sarcoma showing fusion of the ASPL (ASPSCR1) gene on chromosome 17 to the TFE3 transcription factor gene on the X chromosome, producing a fusion transcription factor.","asOf":"2026-09-17","links":[{"label":"Oncogene 2001","url":"https://doi.org/10.1038/sj.onc.1204074"},{"label":"PubMed","url":"https://pubmed.ncbi.nlm.nih.gov/11244503/"}],"tags":[],"related":[],"cancers":["alveolar-soft-part-sarcoma"],"sections":[],"technologies":[],"targets":[],"drugs":[],"companies":[],"institutions":[],"pathways":[],"terms":[],"trials":[],"people":[],"bottlenecks":[],"keyPapers":[],"journals":["oncogene-journal"],"dependsOn":[],"notes":[],"journal":"Oncogene","year":2001,"doi":"10.1038/sj.onc.1204074","pmid":"11244503","authors":"Ladanyi M, Lui MY, Antonescu CR, et al.","paperType":"basic","findings":["ASPL-TFE3 fusion identified as the consistent alteration in alveolar soft part sarcoma."],"whatItMeans":"TFE3 immunostaining and ASPSCR1-TFE3 fusion testing confirm the diagnosis of alveolar soft part sarcoma and link it to a family of TFE3-rearranged tumours including a type of renal cell carcinoma.","caveats":["No direct therapeutic target has followed from the fusion itself."],"changedPractice":true},"route":"/key-papers/paper-ladanyi-aspl-tfe3-oncogene-2001/","neighbours":{"cancer":[{"id":"alveolar-soft-part-sarcoma","kind":"cancer","name":"Alveolar soft part sarcoma","route":"/cancers/alveolar-soft-part-sarcoma/"}],"journal":[{"id":"oncogene-journal","kind":"journal","name":"Oncogene","route":"/journals/oncogene-journal/"}]}}