{"entity":{"id":"paper-laurie-licitra-salivary-systemic-jco-2006","kind":"paper","name":"Systemic therapy in the palliative management of advanced salivary gland cancers (review)","aka":[],"tldr":"This review of chemotherapy in salivary gland cancers concluded that responses are uncommon and short, that observation is reasonable for slowly progressing disease, and that trials of targeted agents based on tumour biology were needed.","summary":"Systematic review of systemic therapy studies in recurrent or metastatic salivary gland carcinoma, summarising response rates to single agents and combinations by histology, the natural history of indolent adenoid cystic carcinoma, and early experience with targeted agents.","asOf":"2026-09-17","links":[{"label":"J Clin Oncol 2006","url":"https://doi.org/10.1200/JCO.2005.05.3025"},{"label":"PubMed","url":"https://pubmed.ncbi.nlm.nih.gov/16763282/"}],"tags":[],"related":[],"cancers":["mucoepidermoid-carcinoma","adenoid-cystic-carcinoma","salivary-duct-carcinoma"],"sections":[],"technologies":[],"targets":[],"drugs":[],"companies":[],"institutions":[],"pathways":[],"terms":[],"trials":[],"people":[],"bottlenecks":[],"keyPapers":[],"journals":["jco"],"dependsOn":[],"notes":[],"journal":"Journal of Clinical Oncology","year":2006,"doi":"10.1200/JCO.2005.05.3025","pmid":"16763282","authors":"Laurie SA, Licitra L.","paperType":"review","findings":[],"whatItMeans":"The observation-first approach for indolent metastases and the move to biomarker-directed therapy (HER2, androgen receptor, NTRK) on the salivary cancer pages follow this review's conclusions.","caveats":["Predates the HER2, androgen receptor and immunotherapy studies that now guide treatment."],"changedPractice":false},"route":"/key-papers/paper-laurie-licitra-salivary-systemic-jco-2006/","neighbours":{"cancer":[{"id":"adenoid-cystic-carcinoma","kind":"cancer","name":"Adenoid cystic carcinoma","route":"/cancers/adenoid-cystic-carcinoma/"},{"id":"mucoepidermoid-carcinoma","kind":"cancer","name":"Mucoepidermoid carcinoma","route":"/cancers/mucoepidermoid-carcinoma/"},{"id":"salivary-duct-carcinoma","kind":"cancer","name":"Salivary duct carcinoma","route":"/cancers/salivary-duct-carcinoma/"}],"journal":[{"id":"jco","kind":"journal","name":"Journal of Clinical Oncology","route":"/journals/jco/"}]}}