{"entity":{"id":"paper-lee-t2-gallbladder-cancer-surgical-strategy-aso-2015","kind":"paper","name":"Surgical Strategy for T2 Gallbladder Cancer According to Tumor Location","aka":[],"tldr":"A Korean series suggesting that muscle-invading gallbladder tumours on the free side may not always need part of the liver removed, while those against the liver bed do.","summary":"Single-centre Korean series of 157 T2 gallbladder cancers resected with curative intent between 2000 and 2011: 33 peritoneal-side and 124 hepatic-side (epicentre in the gallbladder bed or neck); 122 had hepatic resection and 35 did not. After a median follow-up of 40 months, peritoneal-side tumours had better survival (p=0.002). Tumour location, lymph node metastasis, hepatic resection, lymphatic invasion and perineural invasion were independent prognostic factors. The authors recommend hepatic resection for hepatic-side tumours and suggest it is not always necessary for selected peritoneal-side tumours.","asOf":"2026-09-24","links":[{"label":"Ann Surg Oncol 2015","url":"https://doi.org/10.1245/s10434-014-4300-7"},{"label":"PubMed","url":"https://pubmed.ncbi.nlm.nih.gov/25519930/"}],"tags":["gallbladder-evidence"],"related":[],"cancers":["gallbladder"],"sections":[],"technologies":[],"targets":[],"drugs":[],"companies":[],"institutions":[],"pathways":[],"terms":["t2a-versus-t2b","radical-cholecystectomy"],"trials":[],"people":[],"bottlenecks":[],"keyPapers":[],"journals":["annals-of-surgical-oncology"],"dependsOn":[],"notes":[],"journal":"Annals of Surgical Oncology","year":2015,"doi":"10.1245/s10434-014-4300-7","pmid":"25519930","authors":"Lee H, Choi DW, Park JY, et al.","paperType":"observational","findings":["157 T2 tumours: 33 peritoneal-side, 124 hepatic-side; peritoneal-side survival better (p=0.002).","Tumour location, nodal metastasis, hepatic resection, lymphatic and perineural invasion were independent prognostic factors."],"whatItMeans":"One of the series that raised the question of sparing the liver resection in T2a disease; only 33 peritoneal-side tumours, so it poses the question rather than settles it.","caveats":["Single centre, retrospective, small peritoneal-side group.","Location definitions differ from later studies."],"changedPractice":false,"participants":157},"route":"/key-papers/paper-lee-t2-gallbladder-cancer-surgical-strategy-aso-2015/","neighbours":{"cancer":[{"id":"gallbladder","kind":"cancer","name":"Gallbladder cancer","route":"/cancers/gallbladder/"}],"term":[{"id":"radical-cholecystectomy","kind":"term","name":"Radical (extended) cholecystectomy","route":"/terms/radical-cholecystectomy/"},{"id":"t2a-versus-t2b","kind":"term","name":"T2a versus T2b gallbladder cancer (peritoneal side versus hepatic side)","route":"/terms/t2a-versus-t2b/"}],"journal":[{"id":"annals-of-surgical-oncology","kind":"journal","name":"Annals of surgical oncology","route":"/journals/annals-of-surgical-oncology/"}],"idea":[{"id":"idea-gbc-t2a-spare-liver-resection-trial","kind":"idea","name":"A trial of sparing the liver resection in peritoneal-side (T2a) gallbladder cancer","route":"/ideas/idea-gbc-t2a-spare-liver-resection-trial/"}]}}