{"entity":{"id":"paper-lupo-multiplatform-thyroid-nodule-diagn-cytopathol-2020","kind":"paper","name":"Multiplatform molecular test performance in indeterminate thyroid nodules","aka":[],"tldr":"A multicentre study of a combined DNA, RNA and microRNA test on uncertain thyroid nodules.","summary":"The multiplatform test had 95 per cent sensitivity, 90 per cent specificity, a 97 per cent negative predictive value and a 75 per cent positive predictive value.","asOf":"2026-11-04","links":[{"label":"Lupo et al., Diagn Cytopathol 2020","url":"https://doi.org/10.1002/dc.24564"},{"label":"PubMed","url":"https://pubmed.ncbi.nlm.nih.gov/32767735/"}],"tags":[],"related":[],"cancers":["thyroid"],"sections":["diagnostics"],"technologies":["thyroid-fna-molecular"],"targets":[],"drugs":["thygenext-thyramir"],"companies":[],"institutions":[],"pathways":[],"terms":["biomarker"],"trials":[],"people":[],"bottlenecks":[],"keyPapers":[],"journals":[],"dependsOn":[],"notes":[],"journal":"Diagnostic Cytopathology","year":2020,"doi":"10.1002/dc.24564","pmid":"32767735","authors":"Lupo MA, Walts AE, Sistrunk JW, et al.","paperType":"translational","findings":["Sensitivity 95%, specificity 90%, negative predictive value 97%, positive predictive value 75%."],"whatItMeans":"Adding microRNA to DNA and RNA fusion testing gave high negative predictive value.","caveats":["Industry-sponsored."]},"route":"/key-papers/paper-lupo-multiplatform-thyroid-nodule-diagn-cytopathol-2020/","neighbours":{"cancer":[{"id":"thyroid","kind":"cancer","name":"Thyroid cancer","route":"/cancers/thyroid/"}],"section":[{"id":"diagnostics","kind":"section","name":"Diagnostics & Biomarkers","route":"/fronts/diagnostics/"}],"technology":[{"id":"thyroid-fna-molecular","kind":"technology","name":"Thyroid nodule FNA, Bethesda cytology & molecular classifiers","route":"/technologies/thyroid-fna-molecular/"}],"drug":[{"id":"thygenext-thyramir","kind":"drug","name":"ThyGeNEXT and ThyraMIR v2","route":"/drugs/thygenext-thyramir/"}],"term":[{"id":"biomarker","kind":"term","name":"Biomarker","route":"/terms/biomarker/"}]}}