{"entity":{"id":"paper-marinov-single-cell-transcriptome-stochasticity-genome-res-2014","kind":"paper","name":"From single-cell to cell-pool transcriptomes: stochasticity in gene expression and RNA splicing","aka":[],"tldr":"A single-cell study that counted RNA molecules and found tens to hundreds of thousands of messenger RNA molecules in each cell.","summary":"Using added RNA standards of known quantity on single lymphoblastoid cells, the authors estimate between 50,000 and 300,000 transcripts per cell.","asOf":"2026-11-04","links":[{"label":"Marinov et al., Genome Res 2014","url":"https://doi.org/10.1101/gr.161034.113"},{"label":"PubMed","url":"https://pubmed.ncbi.nlm.nih.gov/24299736/"}],"tags":[],"related":[],"cancers":[],"sections":["diagnostics"],"technologies":["single-cell-spatial"],"targets":[],"drugs":[],"companies":[],"institutions":[],"pathways":[],"terms":[],"trials":[],"people":[],"bottlenecks":[],"keyPapers":[],"journals":[],"dependsOn":[],"notes":[],"journal":"Genome Research","year":2014,"doi":"10.1101/gr.161034.113","pmid":"24299736","authors":"Marinov GK, Williams BA, McCue K, et al.","paperType":"basic","findings":["50,000 to 300,000 mRNA molecules per cell."],"whatItMeans":"A cell holds far more RNA molecules than its two copies of each gene, which is the arithmetic behind adding RNA to a DNA blood test.","caveats":["One cell line, not tumour cells; total transcripts, not one gene."]},"route":"/key-papers/paper-marinov-single-cell-transcriptome-stochasticity-genome-res-2014/","neighbours":{"section":[{"id":"diagnostics","kind":"section","name":"Diagnostics & Biomarkers","route":"/fronts/diagnostics/"}],"technology":[{"id":"single-cell-spatial","kind":"technology","name":"Single-cell & spatial profiling","route":"/technologies/single-cell-spatial/"}],"idea":[{"id":"idea-stack-ctdna-and-tumour-rna-residual-disease","kind":"idea","name":"Read tumour RNA and tumour DNA from the same blood draw to find and type residual cancer","route":"/ideas/idea-stack-ctdna-and-tumour-rna-residual-disease/"}]}}