{"entity":{"id":"paper-mateos-20-2-20-smouldering-bcj-2020","kind":"paper","name":"IMWG 20/2/20 risk stratification model for smouldering multiple myeloma","aka":[],"tldr":"A simple score using three numbers, marrow plasma cells over 20 percent, M-protein over 2 grams per decilitre and a free light-chain ratio over 20, sorts smouldering myeloma into risk groups and is used to decide who might be treated early.","summary":"Retrospective study of 1,996 patients with smouldering myeloma from international centres developing a risk model based on marrow plasma cell percentage, M-protein level and involved to uninvolved free light-chain ratio, with cytogenetics as an optional fourth variable.\n\nTwo-year progression risk ranged from about 6 percent with no risk factors to about 44 percent with all three, and the model was validated in an independent cohort.","asOf":"2026-09-17","links":[{"label":"Blood Cancer J 2020","url":"https://doi.org/10.1038/s41408-020-00366-3"},{"label":"PubMed","url":"https://pubmed.ncbi.nlm.nih.gov/33067414/"}],"tags":[],"related":[],"cancers":["smouldering-myeloma"],"sections":[],"technologies":[],"targets":[],"drugs":[],"companies":[],"institutions":[],"pathways":[],"terms":[],"trials":[],"people":[],"bottlenecks":[],"keyPapers":[],"journals":["blood-cancer-journal"],"dependsOn":[],"notes":[],"journal":"Blood cancer journal","year":2020,"doi":"10.1038/s41408-020-00366-3","pmid":"33067414","authors":"Mateos MV, Kumar S, Dimopoulos MA, et al.","paperType":"observational","findings":["Two-year progression risk 6 percent, 18 percent and 44 percent for low, intermediate and high risk.","Adding high-risk cytogenetics improved discrimination."],"whatItMeans":"The 20/2/20 model defines high-risk smouldering myeloma in current guidelines and trial eligibility, including in AQUILA-informed practice.","caveats":["Retrospective and based on values at diagnosis; evolving markers over time also matter."],"changedPractice":true,"participants":1996},"route":"/key-papers/paper-mateos-20-2-20-smouldering-bcj-2020/","neighbours":{"cancer":[{"id":"smouldering-myeloma","kind":"cancer","name":"Smouldering multiple myeloma","route":"/cancers/smouldering-myeloma/"}],"journal":[{"id":"blood-cancer-journal","kind":"journal","name":"Blood cancer journal","route":"/journals/blood-cancer-journal/"}]}}