{"entity":{"id":"paper-mcclements-capbil-incidental-gallbladder-cancer-bjs-2026","kind":"paper","name":"Management of incidental gallbladder cancer in the nationwide CAPBIL study","aka":[],"tldr":"The first UK-wide picture of gallbladder cancers found by chance: across 24 centres over nine years, two thirds went on to liver surgery and those who did stayed free of disease far longer.","summary":"UK HPB Research Collaborative Group study of 285 patients diagnosed with incidental gallbladder cancer after cholecystectomy between January 2014 and December 2022 at 24 UK centres. Median follow-up was 31 months; five-year disease-free survival was 41.5 percent and overall survival 45.1 percent. Of 193 patients (67.7 percent) who underwent liver resection, 97.9 percent had segment 4b/5 resection. Liver resection was associated with longer disease-free survival (51 versus 15 months). Adverse tumour biology was associated with poorer survival.","asOf":"2026-09-24","links":[{"label":"Br J Surg 2026","url":"https://doi.org/10.1093/bjs/znag050"},{"label":"PubMed","url":"https://pubmed.ncbi.nlm.nih.gov/42013358/"}],"tags":["gallbladder-evidence"],"related":["paper-mcclements-capbil-surgical-outcomes-gallbladder-cancer-hpb-2026"],"cancers":["gallbladder"],"sections":[],"technologies":[],"targets":[],"drugs":[],"companies":[],"institutions":["liverpool-hpb-centre"],"pathways":[],"terms":["incidental-gallbladder-cancer","radical-cholecystectomy"],"trials":["bilcap"],"people":["hassan-malik"],"bottlenecks":[],"keyPapers":[],"journals":[],"dependsOn":[],"notes":[],"journal":"British Journal of Surgery","year":2026,"doi":"10.1093/bjs/znag050","pmid":"42013358","authors":"McClements J, Lee WT, Koh A, et al.","paperType":"real-world","findings":["285 incidental gallbladder cancers at 24 UK centres, 2014 to 2022; five-year disease-free survival 41.5 percent, overall survival 45.1 percent.","193 patients (67.7 percent) underwent liver resection, 97.9 percent of them segment 4b/5.","Median disease-free survival 51 months with liver resection vs 15 months without."],"whatItMeans":"This is the UK baseline for the incidental cancer pathway: a re-resection rate well above the Dutch registry's 24 percent, with the same selection caveat. The abstract leaves out the histology, referral and timing detail; the full paper holds it.","caveats":["Retrospective, unmatched comparison; patients not offered surgery were likely sicker or more advanced.","Abstract reports disease-free survival months without confidence intervals."],"changedPractice":false,"participants":285},"route":"/key-papers/paper-mcclements-capbil-incidental-gallbladder-cancer-bjs-2026/","neighbours":{"paper":[{"id":"paper-mcclements-capbil-surgical-outcomes-gallbladder-cancer-hpb-2026","kind":"paper","name":"Surgical outcomes in gallbladder cancer: evidence from the UK nationwide CAPBIL study","route":"/key-papers/paper-mcclements-capbil-surgical-outcomes-gallbladder-cancer-hpb-2026/"}],"cancer":[{"id":"gallbladder","kind":"cancer","name":"Gallbladder cancer","route":"/cancers/gallbladder/"},{"id":"incidental-gallbladder-cancer","kind":"cancer","name":"Incidental gallbladder cancer (found after cholecystectomy)","route":"/cancers/incidental-gallbladder-cancer/"}],"institution":[{"id":"liverpool-hpb-centre","kind":"institution","name":"Liverpool University Hospitals HPB centre (Aintree)","route":"/institutions/liverpool-hpb-centre/"}],"term":[{"id":"radical-cholecystectomy","kind":"term","name":"Radical (extended) cholecystectomy","route":"/terms/radical-cholecystectomy/"}],"trial":[{"id":"bilcap","kind":"trial","name":"BILCAP","route":"/trials/bilcap/"}],"person":[{"id":"hassan-malik","kind":"person","name":"Hassan Malik","route":"/people/hassan-malik/"}],"roadmap":[{"id":"gallbladder-cancer-roadmap","kind":"roadmap","name":"Gallbladder cancer roadmap: from a chance finding at gallstone surgery to a disease with its own trials","route":"/roadmaps/gallbladder-cancer-roadmap/"}],"idea":[{"id":"idea-gbc-national-incidental-cancer-pathway","kind":"idea","name":"A national incidental gallbladder cancer pathway: histology for every gallbladder, referral within two weeks, re-resection by eight","route":"/ideas/idea-gbc-national-incidental-cancer-pathway/"}]}}