{"entity":{"id":"paper-merlo-nat-rev-cancer","kind":"paper","name":"Cancer as an evolutionary and ecological process","aka":[],"tldr":"Paper cited by one term page, indexed on Europe PMC as PubMed record 17109012 and published in Nature Reviews Cancer; the citing page links this DOI, which is how the record was matched.","summary":"Neoplasms are microcosms of evolution. Within a neoplasm, a mosaic of mutant cells compete for space and resources, evade predation by the immune system and can even cooperate to disperse and colonize new organs. The evolution of neoplastic cells explains both why we get cancer and why it has been so difficult to cure. The tools of evolutionary biology and ecology are providing new insights into neoplastic progression and the clinical control of cancer.\n\nIndexed on Europe PMC as PubMed record 17109012 (DOI 10.1038/nrc2013). Matched by DOI alone: one term page cites this DOI among its external links (the pages are listed under Related), and this page was written so that the citation resolves inside OnCo. No figure has been checked by an editor.","asOf":"2026-09-22","links":[{"label":"Nat Rev Cancer 2006","url":"https://doi.org/10.1038/nrc2013"},{"label":"PubMed","url":"https://pubmed.ncbi.nlm.nih.gov/17109012/"},{"label":"Europe PMC","url":"https://europepmc.org/article/MED/17109012"}],"tags":["europepmc-ingest"],"related":["clonal-evolution-theory"],"cancers":[],"sections":[],"technologies":[],"targets":[],"drugs":[],"companies":[],"institutions":[],"pathways":[],"terms":[],"trials":[],"people":[],"bottlenecks":[],"keyPapers":[],"journals":["nature-reviews-cancer"],"dependsOn":[],"notes":[],"journal":"Nature Reviews Cancer","year":2006,"doi":"10.1038/nrc2013","pmid":"17109012","authors":"Merlo LM, Pepper JW, Reid BJ, et al.","paperType":"review","findings":[],"whatItMeans":"One term page on OnCo cites this paper by its DOI; this record gives the citation a page of its own so a reader can follow it without leaving OnCo. Read the abstract above alongside the citing page listed under Related; the record was created automatically from the Europe PMC entry and its figures have not been checked by hand.","caveats":["Matched to the citing OnCo records by DOI alone; the summary reproduces the Europe PMC abstract and no figure has been verified against the full paper."]},"route":"/key-papers/paper-merlo-nat-rev-cancer/","neighbours":{"term":[{"id":"clonal-evolution-theory","kind":"term","name":"Clonal evolution and the ecological view of cancer","route":"/terms/clonal-evolution-theory/"}],"journal":[{"id":"nature-reviews-cancer","kind":"journal","name":"Nature Reviews Cancer","route":"/journals/nature-reviews-cancer/"}]}}