{"entity":{"id":"paper-momen-roknabadi-oncrna-colorectal-clin-cancer-res-2025","kind":"paper","name":"Detection of Early-Stage Colorectal Cancer Using Cell-Free oncRNA Biomarkers and Artificial Intelligence","aka":[],"tldr":"Exai Bio's study of tumour-specific small RNAs in blood for detecting colorectal cancer.","summary":"In the independent validation set of 192, overall sensitivity was 89 per cent at 90 per cent specificity, with 80 per cent sensitivity for stage I.","asOf":"2026-11-04","links":[{"label":"Momen-Roknabadi et al., Clin Cancer Res 2025","url":"https://doi.org/10.1158/1078-0432.ccr-25-0449"},{"label":"PubMed","url":"https://pubmed.ncbi.nlm.nih.gov/40366744/"}],"tags":[],"related":[],"cancers":["colorectal"],"sections":["early-detection"],"technologies":["liquid-rna-biopsy"],"targets":[],"drugs":[],"companies":["exai-bio"],"institutions":[],"pathways":[],"terms":["biomarker"],"trials":[],"people":[],"bottlenecks":[],"keyPapers":[],"journals":[],"dependsOn":[],"notes":[],"journal":"Clinical Cancer Research","year":2025,"doi":"10.1158/1078-0432.ccr-25-0449","pmid":"40366744","authors":"Momen-Roknabadi A, Karimzadeh M, Chen NC, et al.","paperType":"translational","findings":["Sensitivity 89% at 90% specificity; 80% for stage I."],"whatItMeans":"Cell-free orphan RNAs detect early colorectal cancer in a case-control setting.","caveats":["Case-control; company authors."]},"route":"/key-papers/paper-momen-roknabadi-oncrna-colorectal-clin-cancer-res-2025/","neighbours":{"cancer":[{"id":"colorectal","kind":"cancer","name":"Colorectal cancer","route":"/cancers/colorectal/"}],"section":[{"id":"early-detection","kind":"section","name":"Early Detection & Screening","route":"/fronts/early-detection/"}],"technology":[{"id":"liquid-rna-biopsy","kind":"technology","name":"Liquid RNA biopsy (cell-free, vesicle and platelet RNA)","route":"/technologies/liquid-rna-biopsy/"}],"company":[{"id":"exai-bio","kind":"company","name":"Exai Bio","route":"/companies/exai-bio/"}],"term":[{"id":"biomarker","kind":"term","name":"Biomarker","route":"/terms/biomarker/"}]}}