{"entity":{"id":"paper-mrc-te19-carboplatin-seminoma-oliver-lancet-2005","kind":"paper","name":"MRC TE19/EORTC 30982: radiotherapy versus single-dose carboplatin as adjuvant treatment for stage I seminoma","aka":[],"tldr":"A single dose of carboplatin was as effective as radiotherapy in preventing relapse of stage I seminoma after orchidectomy, with less time off work and fewer second testicular cancers, so it replaced radiotherapy for men who choose adjuvant treatment.","summary":"Phase 3 non-inferiority trial of 1,477 men with stage I seminoma randomised to adjuvant radiotherapy or one cycle of carboplatin (AUC 7).\n\nThree-year relapse-free rates were 94.8 percent with carboplatin and 95.9 percent with radiotherapy (non-inferior), with fewer contralateral germ cell tumours after carboplatin and less acute toxicity; longer follow-up confirmed equivalence.","asOf":"2026-09-17","links":[{"label":"Lancet 2005","url":"https://doi.org/10.1016/S0140-6736(05)66984-X"},{"label":"PubMed","url":"https://pubmed.ncbi.nlm.nih.gov/16039331/"}],"tags":[],"related":[],"cancers":["seminoma"],"sections":[],"technologies":[],"targets":[],"drugs":["carboplatin"],"companies":[],"institutions":[],"pathways":[],"terms":[],"trials":[],"people":[],"bottlenecks":[],"keyPapers":[],"journals":["lancet"],"dependsOn":[],"notes":[],"journal":"The Lancet","year":2005,"doi":"10.1016/S0140-6736(05)66984-X","pmid":"16039331","authors":"Oliver RT, Mason MD, Mead GM, et al.","paperType":"rct","findings":["Three-year relapse-free rate 94.8 percent (carboplatin) vs 95.9 percent (radiotherapy); non-inferior.","Contralateral germ cell tumours 2 vs 10 cases."],"whatItMeans":"Single-dose carboplatin is the adjuvant option for stage I seminoma where surveillance is not chosen; radiotherapy is now rarely used because of second cancer risk.","caveats":["Surveillance alone cures the same proportion of men after salvage and is preferred for most today."],"changedPractice":true,"participants":1477},"route":"/key-papers/paper-mrc-te19-carboplatin-seminoma-oliver-lancet-2005/","neighbours":{"cancer":[{"id":"seminoma","kind":"cancer","name":"Seminoma","route":"/cancers/seminoma/"}],"drug":[{"id":"carboplatin","kind":"drug","name":"Carboplatin","route":"/drugs/carboplatin/"}],"journal":[{"id":"lancet","kind":"journal","name":"The Lancet","route":"/journals/lancet/"}]}}