{"entity":{"id":"paper-myxofibrosarcoma-mentzel-ajsp-1996","kind":"paper","name":"Myxofibrosarcoma: clinicopathological analysis of 75 cases with emphasis on the low-grade variant","aka":[],"tldr":"This series defined myxofibrosarcoma as a distinct sarcoma of elderly limbs with characteristic curvilinear blood vessels and a strong tendency to recur locally and progress in grade, features that still guide its wide excision.","summary":"Clinicopathological study of 75 cases of myxofibrosarcoma establishing diagnostic criteria (multinodular growth, myxoid stroma, curvilinear vessels, pleomorphic cells), a grading spectrum from low to high grade, a local recurrence rate of about 50 to 60 percent often with grade progression, and metastasis mainly from high-grade tumours.","asOf":"2026-09-17","links":[{"label":"Am J Surg Pathol 1996","url":"https://doi.org/10.1097/00000478-199604000-00001"},{"label":"PubMed","url":"https://pubmed.ncbi.nlm.nih.gov/8604805/"}],"tags":[],"related":[],"cancers":["myxofibrosarcoma"],"sections":[],"technologies":[],"targets":[],"drugs":[],"companies":[],"institutions":[],"pathways":[],"terms":[],"trials":[],"people":[],"bottlenecks":[],"keyPapers":[],"journals":[],"dependsOn":[],"notes":[],"journal":"American Journal of Surgical Pathology","year":1996,"doi":"10.1097/00000478-199604000-00001","pmid":"8604805","authors":"Mentzel T, Calonje E, Wadden C, et al.","paperType":"observational","findings":["Local recurrence in over half of cases regardless of grade, with progression to higher grade in a proportion.","Metastasis mostly from intermediate- and high-grade tumours."],"whatItMeans":"The recognition that myxofibrosarcoma infiltrates along tissue planes far beyond the visible mass underlies the wide, MRI-planned excision and adjuvant radiotherapy recommended today.","caveats":["Retrospective pathology series."],"changedPractice":true,"participants":75},"route":"/key-papers/paper-myxofibrosarcoma-mentzel-ajsp-1996/","neighbours":{"cancer":[{"id":"myxofibrosarcoma","kind":"cancer","name":"Myxofibrosarcoma","route":"/cancers/myxofibrosarcoma/"}]}}