{"entity":{"id":"paper-nelson-j-med-chem","kind":"paper","name":"The Essential Medicinal Chemistry of Curcumin","aka":[],"tldr":"Paper cited by one technology page, indexed on Europe PMC as PubMed record 28074653 and published in Journal of medicinal chemistry; the citing page links this DOI, which is how the record was matched.","summary":"Curcumin is a constituent (up to ∼5%) of the traditional medicine known as turmeric. Interest in the therapeutic use of turmeric and the relative ease of isolation of curcuminoids has led to their extensive investigation. Curcumin has recently been classified as both a PAINS (pan-assay interference compounds) and an IMPS (invalid metabolic panaceas) candidate. The likely false activity of curcumin in vitro and in vivo has resulted in >120 clinical trials of curcuminoids against several diseases. No double-blinded, placebo controlled clinical trial of curcumin has been successful. This manuscript reviews the essential medicinal chemistry of curcumin and provides evidence that curcumin is an unstable, reactive, nonbioavailable compound and, therefore, a highly improbable lead. On the basis of this in-depth evaluation, potential new directions for research on curcuminoids are discussed.\n\nIndexed on Europe PMC as PubMed record 28074653 (DOI 10.1021/acs.jmedchem.6b00975). Matched by DOI alone: one technology page cites this DOI among its external links (the pages are listed under Related), and this page was written so that the citation resolves inside OnCo. No figure has been checked by an editor.","asOf":"2026-09-22","links":[{"label":"J Med Chem 2017","url":"https://doi.org/10.1021/acs.jmedchem.6b00975"},{"label":"PubMed","url":"https://pubmed.ncbi.nlm.nih.gov/28074653/"},{"label":"Europe PMC","url":"https://europepmc.org/article/MED/28074653"}],"tags":["europepmc-ingest"],"related":["curcumin-turmeric"],"cancers":[],"sections":[],"technologies":[],"targets":[],"drugs":[],"companies":[],"institutions":[],"pathways":[],"terms":[],"trials":[],"people":[],"bottlenecks":[],"keyPapers":[],"journals":[],"dependsOn":[],"notes":[],"journal":"Journal of medicinal chemistry","year":2017,"doi":"10.1021/acs.jmedchem.6b00975","pmid":"28074653","authors":"Nelson KM, Dahlin JL, Bisson J, et al.","paperType":"review","findings":[],"whatItMeans":"One technology page on OnCo cites this paper by its DOI; this record gives the citation a page of its own so a reader can follow it without leaving OnCo. Read the abstract above alongside the citing page listed under Related; the record was created automatically from the Europe PMC entry and its figures have not been checked by hand.","caveats":["Matched to the citing OnCo records by DOI alone; the summary reproduces the Europe PMC abstract and no figure has been verified against the full paper."]},"route":"/key-papers/paper-nelson-j-med-chem/","neighbours":{"technology":[{"id":"curcumin-turmeric","kind":"technology","name":"Curcumin and turmeric","route":"/technologies/curcumin-turmeric/"}]}}