{"entity":{"id":"paper-nimir-ar-v7-ctc-ctrna-exosomes-cells-2019","kind":"paper","name":"Detection of AR-V7 in Liquid Biopsies of Castrate Resistant Prostate Cancer Patients: A Comparison of AR-V7 Analysis in Circulating Tumor Cells, Circulating Tumor RNA and Exosomes","aka":[],"tldr":"A head-to-head comparison of three blood compartments for a prostate cancer resistance RNA, in which circulating tumour cells beat cell-free and vesicle RNA.","summary":"AR and AR-V7 RNA were detectable in circulating tumour cells, circulating tumour RNA and exosomes, and AR-V7 detection from circulating tumour cells showed higher sensitivity than detection from cell-free RNA and exosomes.","asOf":"2026-11-04","links":[{"label":"Nimir et al., Cells 2019","url":"https://doi.org/10.3390/cells8070688"},{"label":"PubMed","url":"https://pubmed.ncbi.nlm.nih.gov/31288377/"}],"tags":[],"related":[],"cancers":["prostate-mcrpc"],"sections":["diagnostics"],"technologies":["liquid-rna-biopsy"],"targets":[],"drugs":[],"companies":[],"institutions":[],"pathways":[],"terms":["ar-v7"],"trials":[],"people":[],"bottlenecks":[],"keyPapers":[],"journals":[],"dependsOn":[],"notes":[],"journal":"Cells","year":2019,"doi":"10.3390/cells8070688","pmid":"31288377","authors":"Nimir M, Ma Y, Jeffreys SA, et al.","paperType":"translational","findings":["AR-V7 more sensitive from tumour cells than from cell-free RNA or exosomes."],"whatItMeans":"Reading a phenotype from cell-free RNA can be less sensitive than from whole tumour cells in blood.","caveats":["Small cohort."],"participants":44},"route":"/key-papers/paper-nimir-ar-v7-ctc-ctrna-exosomes-cells-2019/","neighbours":{"cancer":[{"id":"prostate-mcrpc","kind":"cancer","name":"Metastatic castration-resistant prostate cancer","route":"/cancers/prostate-mcrpc/"}],"section":[{"id":"diagnostics","kind":"section","name":"Diagnostics & Biomarkers","route":"/fronts/diagnostics/"}],"technology":[{"id":"liquid-rna-biopsy","kind":"technology","name":"Liquid RNA biopsy (cell-free, vesicle and platelet RNA)","route":"/technologies/liquid-rna-biopsy/"}],"term":[{"id":"ar-v7","kind":"term","name":"AR-V7 splice variant","route":"/terms/ar-v7/"}],"idea":[{"id":"idea-stack-ctdna-and-tumour-rna-residual-disease","kind":"idea","name":"Read tumour RNA and tumour DNA from the same blood draw to find and type residual cancer","route":"/ideas/idea-stack-ctdna-and-tumour-rna-residual-disease/"}]}}