{"entity":{"id":"paper-nordic-nec-sorbye-ann-oncol-2013","kind":"paper","name":"NORDIC NEC: predictive and prognostic factors in 305 patients with advanced gastrointestinal neuroendocrine carcinoma","aka":[],"tldr":"This large Nordic series showed that gastrointestinal neuroendocrine carcinomas with a Ki-67 below 55 percent respond poorly to platinum-etoposide yet live longer than those above it, which led to the separation of grade 3 neuroendocrine tumours from carcinomas.","summary":"Retrospective analysis of 305 patients with advanced gastrointestinal high-grade (grade 3) neuroendocrine carcinoma treated at Nordic centres, examining response to first-line platinum-based chemotherapy and survival by clinical and pathological features.\n\nResponse to platinum chemotherapy was 42 percent for Ki-67 of 55 percent or more but 15 percent below it, while survival was longer in the lower Ki-67 group (median 14 versus 10 months); performance status, primary site and lactate dehydrogenase were also prognostic.","asOf":"2026-09-17","links":[{"label":"Ann Oncol 2013","url":"https://doi.org/10.1093/annonc/mds276"},{"label":"PubMed","url":"https://pubmed.ncbi.nlm.nih.gov/22967994/"}],"tags":[],"related":[],"cancers":["extrapulmonary-nec"],"sections":[],"technologies":[],"targets":[],"drugs":[],"companies":[],"institutions":[],"pathways":[],"terms":[],"trials":[],"people":[],"bottlenecks":[],"keyPapers":[],"journals":["annals-of-oncology"],"dependsOn":[],"notes":[],"journal":"Annals of Oncology","year":2013,"doi":"10.1093/annonc/mds276","pmid":"22967994","authors":"Sorbye H, Welin S, Langer SW, et al.","paperType":"observational","findings":["Response to platinum chemotherapy 42 percent with Ki-67 of 55 percent or more vs 15 percent below.","Median survival 14 months with Ki-67 under 55 percent vs 10 months above."],"whatItMeans":"The 55 percent Ki-67 threshold and the recognition that well-differentiated grade 3 tumours behave differently from carcinomas, now embedded in the WHO classification, came from this analysis.","caveats":["Retrospective; morphology (well versus poorly differentiated) was not systematically recorded."],"changedPractice":true,"participants":305},"route":"/key-papers/paper-nordic-nec-sorbye-ann-oncol-2013/","neighbours":{"cancer":[{"id":"extrapulmonary-nec","kind":"cancer","name":"Extrapulmonary neuroendocrine carcinoma","route":"/cancers/extrapulmonary-nec/"}],"journal":[{"id":"annals-of-oncology","kind":"journal","name":"Annals of Oncology","route":"/journals/annals-of-oncology/"}]}}