{"entity":{"id":"paper-oncoseek-npj-precis-oncol-2025","kind":"paper","name":"A large-scale, multi-centre validation study of an AI-empowered blood-based test for multi-cancer early detection","aka":[],"tldr":"Pooling seven centres in three countries and 15,122 people, the OncoSeek protein test found about six in ten cancers with about eight false positives per hundred people without cancer.","summary":"Shen and colleagues combined four new cohorts with the earlier training and validation sets: 15,122 participants (3,029 with cancer) from seven centres in three countries, on four platforms and two sample types. OncoSeek had an area under the curve of 0.829, 58.4% sensitivity, 92.0% specificity and 70.6% tissue-of-origin accuracy in true positives, across 14 cancer types with sensitivities of 38.9% to 83.3%. In a symptomatic cohort it had 73.1% sensitivity at 90.6% specificity.","asOf":"2026-10-29","links":[{"label":"npj Precision Oncology 2025","url":"https://doi.org/10.1038/s41698-025-01105-2"},{"label":"PubMed","url":"https://pubmed.ncbi.nlm.nih.gov/41062647/"}],"tags":[],"related":[],"cancers":[],"sections":["early-detection"],"technologies":["mced","proteomics"],"targets":[],"drugs":["oncoseek"],"companies":["seekin"],"institutions":[],"pathways":[],"terms":[],"trials":[],"people":[],"bottlenecks":[],"keyPapers":[],"journals":[],"dependsOn":[],"notes":[],"journal":"npj Precision Oncology","year":2025,"doi":"10.1038/s41698-025-01105-2","pmid":"41062647","authors":"Shen Y, Xia Y, Chang Y, et al.","paperType":"observational","findings":["58.4% sensitivity, 92.0% specificity across 14 cancers.","Symptomatic cohort: 73.1% sensitivity at 90.6% specificity."],"whatItMeans":"Consistent across sites and platforms, with the same limit as before: specificity too low for population screening without a second test.","caveats":["Mostly retrospective and case-control cohorts.","Authors include SeekIn staff."],"changedPractice":false,"participants":15122},"route":"/key-papers/paper-oncoseek-npj-precis-oncol-2025/","neighbours":{"section":[{"id":"early-detection","kind":"section","name":"Early Detection & Screening","route":"/fronts/early-detection/"}],"technology":[{"id":"mced","kind":"technology","name":"Multi-cancer early detection (MCED)","route":"/technologies/mced/"},{"id":"proteomics","kind":"technology","name":"Proteomics & phosphoproteomics","route":"/technologies/proteomics/"}],"drug":[{"id":"oncoseek","kind":"drug","name":"OncoSeek","route":"/drugs/oncoseek/"}],"company":[{"id":"seekin","kind":"company","name":"SeekIn","route":"/companies/seekin/"}]}}